| Title: |
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: Insights on the role of methionine |
| Authors: |
Shosham, MS; Shalev, DE; Adriaens, W Wencke; Merkx, M Maarten; Hackeng, TM Tilman; Tshuva, EY |
| Source: |
ISSN:1359-7345. |
| Publication Year: |
2011 |
| Collection: |
Eindhoven University of Technology (TU/e): Research Portal |
| Description: |
The first NMR structure of a Cu(I)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH 3.0 and 6.8 Cu(I) binds through one Cys and the Met rather than the two Cys residues, differently than at pH 8.5. This suggests a possible role of Met in metal transport. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://repository.tue.nl/713304 |
| Availability: |
http://repository.tue.nl/713304 |
| Rights: |
Copyright (c) Shosham, MS ; Copyright (c) Shalev, DE ; Copyright (c) Adriaens, W Wencke ; Copyright (c) Merkx, M Maarten ; Copyright (c) Hackeng, TM Tilman ; Copyright (c) Tshuva, EY |
| Accession Number: |
edsbas.5A57E05A |
| Database: |
BASE |