| Title: |
451. Comparative Effectiveness of Dalbavancin Versus Standard Therapy for Staphylococcus aureus Endocarditis in People Who Inject Drugs: A Retrospective, Propensity-Matched Cohort Study Using Real-World Data |
| Authors: |
Ssentongo, Paddy; Papp, Silvana Ribeiro; Papp, Silvana; Banjade, Rashmi |
| Source: |
Open Forum Infectious Diseases ; volume 13, issue Supplement_1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background People who inject drugs (PWID) with Staphylococcus aureus infective endocarditis often face barriers to completing prolonged intravenous antibiotic regimens. Discharging PWID with peripherally inserted central catheters (PICCs) raises safety concerns, including potential line misuse, leading to complications and treatment failure. Dalbavancin, a long-acting lipoglycopeptide, may offer a safer, more practical alternative, but its comparative effectiveness remains uncertain.Figure 1.Co-morbidities and Types of Substance Use Among Patients with Staphylococcus aureus Endocarditis Receiving Dalbavancin vs Standard Therapy. This panel illustrates the frequency (%) of key co-morbid conditions and substance use diagnoses among propensity score–matched cohorts (n=288 per group). Black bars represent patients treated with dalbavancin; red bars represent those receiving standard intravenous antibiotic therapy. Horizontal bars show group frequencies with 95% confidence intervalsFigure 2.Comparison of Laboratory Values Between Dalbavancin and Standard Therapy Groups After Propensity Score Matching. Boxplots show the distribution of selected laboratory measurements for patients with endocarditis who received either dalbavancin (black) or standard therapy (dark red), following 1:1 propensity score matching. Laboratory values represent the most recent result recorded within 365 days after the index event (initiation of cohort-defining therapy Methods Using the TriNetX Global Collaborative Network, we conducted a retrospective, real-world, propensity score–matched cohort study of adults (≥18 years) with S. aureus infective endocarditis and substance use history. Patients receiving dalbavancin (n=288) were matched 1:1 to those receiving standard intravenous antibiotics (vancomycin, daptomycin, cefazolin, linezolid, or nafcillin; n=288). Matching was based on age and sex. The primary outcome was 1-year all-cause mortality. Secondary outcomes included recurrent bacteremia, acute kidney injury (AKI), ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf695.150 |
| Availability: |
https://doi.org/10.1093/ofid/ofaf695.150; https://academic.oup.com/ofid/article-pdf/13/Supplement_1/ofaf695.150/66343260/ofaf695.150.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5ACBBDEB |
| Database: |
BASE |