| Title: |
Salivary biomarkers for diagnosis and therapy monitoring in patients with heart failure. A systematic review |
| Authors: |
Rammos, Aidonis; Bechlioulis, Aris; Kalogeras, Petros; Tripoliti, Evanthia, E; Goletsis, Yorgos; Kalivi, Anna; Blathra, Effrosyni; Salvo, Pietro; Trivella, M. Giovanna, Giovanna; Lomonaco, Tommaso; Fuoco, Roger; Bellagambi, Francesca; Watson, Chris, J; Errachid, Abdelhamid; Fotiadis, Dimitrios, I; Michalis, Lampros, K; Naka, Katerina, K |
| Contributors: |
Second Department of Cardiology; University of Ioannina; Department of Biomedical Research; Institute of Molecular Biology and Biotechnology (IMBB); Department of Economics; Institute of Clinical Physiology (IFC); National Research Council of Italy; Department of Chemistry and Industrial Chemistry; University of Pisa Italy = Università di Pisa Italia = Université de Pise Italie (UniPi); ISA-Micro & Nanobiotechnologies; Institut des Sciences Analytiques (ISA); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); UCD Conway Institute; University College Dublin Dublin (UCD); Wellcome-Wolfson Institute for Experimental Medicine; Queen's University Belfast (QUB); Unit of Medical Technology and Intelligent Information Systems |
| Source: |
ISSN: 2075-4418 ; Diagnostics ; https://hal.science/hal-03249942 ; Diagnostics, 2021, 11 (5), pp.824. ⟨10.3390/diagnostics11050824⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2021 |
| Collection: |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
| Subject Terms: |
biomarkers; heart failure; saliva; diagnosis; therapy monitoring; [CHIM]Chemical Sciences; [CHIM.ANAL]Chemical Sciences/Analytical chemistry; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Biology |
| Description: |
International audience ; The aim of this study was to perform a systematic review on the potential value of saliva biomarkers in the diagnosis, management and prognosis of heart failure (HF). The correlation between saliva and plasma values of these biomarkers was also studied. PubMed was searched to collect relevant literature, i.e., case-control, cross-sectional studies that either compared the values of salivary biomarkers among healthy subjects and HF patients, or investigated their role in risk stratification and prognosis in HF patients. No randomized control trials were included. The search ended on 31st of December 2020. A total of 15 studies met the inclusion criteria. 18 salivary biomarkers were analyzed and the levels of all biomarkers studied were found to be higher in HF patients compared to controls, except for amylase, sodium, and chloride that had smaller saliva concentrations in HF patients. Natriuretic peptides are the most commonly used plasma biomarkers in the management of HF. Their saliva levels show promising results, although the correlation of saliva to plasma values is weakened in higher plasma values. In most of the publications, differences in biomarker levels between HF patients and controls were found to be statistically significant. Due to the small number of patients included, larger studies need to be conducted in order to facilitate the use of saliva biomarkers in clinical practice. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/diagnostics11050824 |
| Availability: |
https://hal.science/hal-03249942; https://hal.science/hal-03249942v1/document; https://hal.science/hal-03249942v1/file/Salivary%20Biomarkers%20for%20Diagnosis%20and%20Therapy%20Monitoring%20in%20Patients%20with%20Heart%20Failure.%20A%20Systematic%20Review.pdf; https://doi.org/10.3390/diagnostics11050824 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5AD4F7B4 |
| Database: |
BASE |