| Title: |
LOW GRADE GLIOMAS |
| Authors: |
Shih, Chie-Schin; Ekoma, Sandra; Ho, Chang; Pradhan, Kamnesh; Hwang, Eugene; Jakacki, Regina; Fisher, Michael; Kilburn, Lindsay; Horn, Marianna; Vezina, Gilbert; Rood, Brian; Packer, Roger; Mittal, Rakesh; Omar, Sahar; Khalifa, Nisreen; Bedir, Rania; Avery, Robert; Acosta, Maria; Hutcheson, Kelly; Santos, Domiciano; Zand, Dina; Rosenbaum, Kenneth; Kalin-Hajdu, Evan; Ospina, Luis; Carret, Anne-Sophie; Marzouki, Monia; Décarie, Jean-Claude; Freeman, Ellen; Hershon, Linda; Warmuth-Metz, Monika; Zurakowski, David; Bison, Brigitte; Falkenstein, Fabian; Gnekow, Astrid; Ehrstedt, Christoffer; Laurencikas, Evaldas; Björklund, Ann-Christin; Strömberg, Bo; Hedborg, Fredrik; Pfeifer, Susan; Bertin, Daniele; Packer, Roger J.; Vallero, Stefano; Basso, Maria Eleonora; Romano, Erica; Peretta, Paola; Morra, Isabella; D'Alonzo, Gabriella; Fagioli, Franca; Toledano, Helen; Laviv, Yossi; Dratviman-Storobinsky, Olga; Michowiz, Shalom; Yaniv, Isaac; Cohen, Ian J.; Goldenberg-Cohen, Nitza; Müller, Klaus; Pietsch, Torsten; Zwiener, Isabella; Meyer, Frank-Michael; Micke, Oliver; Hoffmann, Wolfgang; Kortmann, Rolf-Dieter; Shofty, Ben; Ben-Sira, Liat; Roth, Jonathan; Constantini, Shlomi; Weizmann, Lior; Joskowicz, Leo; Kesler, Anat; Ben-Bashat, Dafna; Yalon, Michal; Dvir, Rina; Freedman, Sigal; Bandopadhayay, Pratiti; Dagi, Linda; Robison, Nathan; Goumnerova, Liliana; Ullrich, Nicole; Opocher, Enrico; De Salvo, Gian Luca; De Paoli, Angela; Simmons, Ian; Sehested, Astrid; Walker, David A.; Picton, Susan V.; Grill, Jacques; Driever, Pablo Hernàiz; Azizi, Amedeo A.; Viscardi, Elisabetta; Perilongo, Giorgio; Cappellano, Andrea M.; Bouffet, Eric; Silva, Frederico; Paiva, Priscila; Cavalheiro, Sergio; Seixas, Maria Teresa; Silva, Nasjla Saba; Antony, Reuben; Fraser, Kenneth; Lin, Julian; Kwiecien, Robert; Mirow, Cora; Thieme, Barbara; von Hornstein, Stephan; Faldum, Andreas; Gnekow, Astrid K.; Bokshtein, Felix; Panandiker, Atmaram Pai; Klimo, Paul; Thompson, Clinton; Armstrong, Greg; Kun, Larry; Boop, Frederick; Sanford, Alex; Örge, Faruk; Laschinger, Kelly; Gold, Deborah; Bangert, Barbara; Stearns, Duncan; Senerchia, Andreza; Walker, David; Picton, Sue; Stokland, Tore; van Meeteren, Antoinette Schouten; Slavc, Irene; de Salvo, Gian Luca; for the SIOP-Europe Low Grade Glioma Working Group; Fernandez, Karen S.; Lulla, Rishi R.; Flores, Mauricio; Benavides, Valeria C.; Mitchell, Craig; AlKofide, Amani; Hassonah, Maher; Khafagh, Yasser; Ayas, Mouhab Ayas; AlFawaz, Ibrahim; Anas, Mohamed; Barria, Mary; Siddiqui, Khawar; Al-Shail, Essam; Fisher, Michael J.; Ullrich, Nicole J.; Ferner, Rosalie E.; Gutmann, David H.; Listernick, Robert; Tabori, Uri; Hoffman, Robert O.; Ardern-Holmes, Simone L.; Hummel, Trent R.; Hargrave, Darren R.; Charrow, Joel; Loguidice, Michael; Balcer, Laura J.; Liu, Grant T.; Jeeva, Irfan; Nelson, Olywn; Guy, Danielle; Damani, Alisha; Gogi, Devina; Picton, Susan; Nelson, Olwyn; Dewsbery, Simon; Sievert, Angela J.; Lang, Shih-Shan; Boucher, Katie; Slaunwhite, Erin; Brewington, Danielle; Madsen, Peter; Storm, Phillip B.; Resnick, Adam C.; Hemenway, Molly; Madden, Jennifer; Macy, Margaret; Foreman, Nicholas; Rush, Sarah; Mascelli, Samantha; Raso, Alessandro; Barla, Annalisa; Nozza, Paolo; Biassoni, Roberto; Pignatelli, Sara; Cama, Armando; Verri, Alessandro; Capra, Valeria; Garrè, MariaLuisa; Bergthold, Guillaume; Piette, Caroline; Raquin, Marie-Anne; Dufour, Christelle; Varlet, Pascale; Dhermain, Frédéric; Puget, Stéphanie; Sainte-Rose, Christian; Abely, Michel; Canale, Sandra; Terashima, Keita; Chow, Kevin; Jones, Jeremy; Ahern, Charlotte; Jo, Eunji; Ellezam, Benjamin; Paulino, Arnold; Okcu, M. Fatih; Su, Jack; Adesina, Adekunle; Mahajan, Anita; Dauser, Robert; Whitehead, William; Lau, Ching; Chintagumpala, Murali; Kebudi, Rejin; Tuncer, Samuray; Cakir, Fatma Betul; Gorgun, Omer; Agaoglu, Fulya Yaman; Ayan, Inci; Darendeliler, Emin; Wolf, David; Cohen, Kenneth; Jeyapalan, Jennie N.; Morley, Isabel C. F.; Hill, Alfred A.; Tatevossian, Ruth G.; Qaddoumi, Ibrahim; Ellison, David W.; Sheer, Denise; Donson, Andrew; Barton, Valerie; Birks, Diane; Kleinschmidt-DeMasters, B. K.; Handler, Michael; Tatevossian, Ruth; Tang, Bo; Dalton, James; Shurtleff, Sheila; Punchihewa, Chandanamalie; Orisme, Wilda; Neale, Geoff; Gajjar, Amar; Baker, Suzanne; Ellison, David; Gilheeney, Stephen; Jamzadeh, Asha; Winchester, Marilyn; Yataghene, Karima; De Braganca, Kevin; Khakoo, Yasmin; Lyden, David; Dunkel, Ira; Terasaki, Mizuhiko; Eto, Tomoko; Morioka, Motohiro; Ho, Cheng-Ying; Bar, Eli; Giannini, Caterina; Karajannis, Matthias A.; Zagzag, David; Eberhart, Charles G.; Rodriguez, Fausto J.; Lee, Yiyen; Bartels, Ute; Huang, Annie; Zaky, Wafik; Bluml, Stefan; Grimm, John; Wong, Kenneth; McComb, Gordon; Gilles, Floyd; Finlay, Jonathan; Dhall, Girish; Chen, Hsin-Hung; Chen, Yi-Wei; Chang, Feng-Chi; Lin, Shih-Chieh; Chang, Kai-Ping; Ho, Donald M.; Wong, Tai-Tong; Lee, Cheng-Chia; Fox, Richard; Wheatley, Keith; van Meeteren, Antoinette YN Schouten; Phuakpet, Kamon; Kulkarni, Abhaya; Laperriere, Normand; Epari, Sridhar; Nair, Vimoj; Gupta, Tejpal; Patil, Pramod; Moiyadi, Aliasgar; Shetty, Prakash; Kane, Shubhada; Jalali, Rakesh; Dorris, Kathleen; Nadi, Mustafa; Sutton, Mary; Wang, Lily; Stogner, Kimberly; Li, Dandan; Hurwitz, Brian; Stevenson, Charles; Miles, Lili; Kim, Mi-Ok; Fuller, Christine; Hawkins, Cynthia; Jones, Blaise; Drake, James; Fouladi, Maryam; Fontebasso, Adam M.; Shirinian, Margret; Jones, David T. W.; Quang, Dong Anh Khuong; Jacob, Karine; Cin, Huriye; Witt, Hendrik; Gerges, Noha; Montpetit, Alexandre; Brunet, Sebastien; Lepage, Pierre; Klekner, Almos; Lambert, Sally; Kwan, Tony; Collins, V. Peter; Albrecht, Steffen; Pfister, Stefan M.; Jabado, Nada; Arrington, Daniel; Manley, Peter; Kieran, Mark; Chi, Susan; Chordas, Christine |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2012 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
Intracranial or spinal dissemination is commonly seen in intracranial malignant tumors and connotes a bad prognostic feature. Low grade gliomas (LGG) are the most common solid tumors in children and are considered non-malignant. However, leptomeningeal metastasis has been reported in these tumors as well. To date, there has been a paucity of information available about prognosis and survival in patients with LGG with multi-focal disease or spinal metastasis. We performed a retrospective review of all children diagnosed with low-grade glioma at Riley Hospital for Children over a span of 17 years (1974-2011). Of 429 patients identified with low-grade glioma, the incidence of multi-focal or metastatic disease was 4.2% (18 patients). The mean age of diagnosis was 5.44 years (range 0.17-15.61 years). The majority of the patients had pilocytic astrocytoma (88.8%). One pilomyxoid astrocytoma and one fibrillary astrocytoma was seen. Mean follow-up time was 76 months. 5 year overall survival rate was 94.4%. 5 year event free survival was 44.5% as 10/18 patients required additional salvage therapy with either chemotherapy or radiation therapy. Children under the age of 3 at diagnosis tended to have a higher risk for refractory disease. In conclusion, children with intracranial multi-focal or disseminated low-grade glioma have a high risk of recurrence but maintain an excellent overall survival rate. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/14/suppl_1/i69; http://dx.doi.org/10.1093/neuonc/nos092 |
| DOI: |
10.1093/neuonc/nos092 |
| Availability: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/14/suppl_1/i69; https://doi.org/10.1093/neuonc/nos092 |
| Rights: |
Copyright (C) 2012, Society for Neuro-Oncology (SNO) |
| Accession Number: |
edsbas.5B11FF5B |
| Database: |
BASE |