| Title: |
Impact of under-assisted ventilation on diaphragm function and structure in a porcine model |
| Authors: |
Capdevila, Mathieu; Pensier, Joris; de Jong, Audrey; Jung, Boris; Beghin, July; Laumon, Thomas; Aarab, Yassir; Deffontis, Lucas; Sfara, Thomas; Cuny, Ambre; Carr, Julie; Molinari, Nicolas; Le Guennec, Jean-Yves; Raynaud, Fabrice; Matecki, Stefan; Brochard, Laurent; Lacampagne, Alain; Jaber, Samir |
| Contributors: |
Hôpital Saint Eloi CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Hôpital Lapeyronie CHU Montpellier; Médecine de précision par intégration de données et inférence causale (PREMEDICAL); Centre Inria d'Université Côte d'Azur; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Desbrest d'Epidémiologie et de Santé Publique (IDESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Institut Desbrest d'Epidémiologie et de Santé Publique (IDESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Interdepartmental Division of Critical Care Medicine; University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute Toronto; Support was provided solely from institutional and/or departmental sources. |
| Source: |
ISSN: 0003-3022 ; Anesthesiology ; https://hal.science/hal-04911765 ; Anesthesiology, 2025, ⟨10.1097/ALN.0000000000005390⟩. |
| Publisher Information: |
CCSD; Lippincott, Williams & Wilkins |
| Publication Year: |
2025 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background: Long-term controlled mechanical ventilation (CMV) in intensive care unit (ICU) induces ventilatory-induced-diaphragm-dysfunction (VIDD). The transition from CMV to assisted mechanical ventilation is a challenge that requires clinicians to balance over-assistance and under-assistance. While the effects of over-assistance on the diaphragm are well known, we aimed to assess the impact of under-assistance on diaphragm function and structure in piglet model with pre-existing VIDD (after long-term CMV) or without VIDD (short-term CMV). Methods: Twenty-two Large-White female piglets were anesthetized, ventilated, and separated into two groups: a VIDD group (n=10) with long-term 72-hour CMV, and a no-VIDD group (n=12) with short-term 2-hour CMV. After sedation reduction at the end of CMV period, each piglet was switched to under-assisted ventilation for 2 hours. Diaphragm function (supramaximal diaphragm pressure-generating capacity assessed by negative tracheal pressure after transvenous phrenic nerve stimulation) and diaphragm structure (mini-invasive in vivo biopsies) were assessed before and after under-assisted ventilation. Results: In VIDD group, supramaximal diaphragm pressure-generating capacity decreased by 22% from 69.9±12.7 to 54.9±19.7 cmH2O ( p =0.04) after 72 hours of CMV evidencing VIDD, then dropped by a further 29% from 54.9±19.7 to 38.9±15.5 cmH2O ( p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/ALN.0000000000005390 |
| Availability: |
https://hal.science/hal-04911765; https://hal.science/hal-04911765v1/document; https://hal.science/hal-04911765v1/file/2025%20Capdevila%20et%20al.,%20Impact%20of%20under.pdf; https://doi.org/10.1097/ALN.0000000000005390 |
| Rights: |
https://hal.science/licences/copyright/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5B228FA6 |
| Database: |
BASE |