| Title: |
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians |
| Authors: |
Li, H; Kilpeläinen, TO; Liu, C; Zhu, J; Liu, Y; Hu, C; Yang, Z; Zhang, W; Bao, W; Cha, S; Wu, Y; Yang, T; Sekine, A; Choi, BY; Yajnik, CS; Zhou, D; Takeuchi, F; Yamamoto, K; Chan, JC; Mani, KR; Been, LF; Imamura, M; Nakashima, E; Lee, N; Fujisawa, T; Karasawa, S; Wen, W; Joglekar, CV; Lu, W; Chang, Y; Xiang, Y; Gao, Y; Liu, S; Song, Y; Kwak, SH; Shin, HD; Park, KS; Fall, CHD; Kim, JY; Sham, PC; Lam, KSL; Zheng, W; Shu, X; Deng, H; Ikegami, H; Krishnaveni, GV; Sanghera, DK; Chuang, L; Liu, L; Hu, R; Kim, Y; Daimon, M; Hotta, K; Jia, W; Kooner, JS; Chambers, JC; Chandak, GR; Ma, RC; Maeda, S; Dorajoo, R; Yokota, M; Takayanagi, R; Kato, N; Lin, X; Loos, RJF |
| Publisher Information: |
//link.springer.de/link/service/journals/00125/index.htm; Germany |
| Publication Year: |
2012 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Subject Terms: |
Asians; FTO; Meta-analysis; Obesity. Type 2 diabetes; Adult; Asian Continental Ancestry Group - genetics; Diabetes Mellitus; Type 2 - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Obesity - genetics; Polymorphism; Single Nucleotide; Proteins - genetics |
| Description: |
Aims/hypothesis FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. Methods All studies published on the association between FTO-rs9939609 (or proxy [r2>0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. Results The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p=9.0×10 -19), overweight by 1.13-fold/allele (p=1.0×10 -11) and type 2 diabetes by 1.15-fold/allele (p=5.5×10 -8). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p=6.6×10 -5). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m 2 per allele (p=2.8×10 -17), WHR by 0.003/allele (p=1.2×10 -6), and body fat percentage by 0.31%/allele (p=0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12-20%) than South Asians (30-33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations. Conclusions/interpretation FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI. © 2012 Springer-Verlag. ; published_or_final_version ; Springer Open Choice, 25 May 2012 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Diabetologia; http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862564504&selection=ref&src=s&origin=recordpage; 995; 213325; WOS:000301182000015; PMC3296006; 981; https://hub.hku.hk/handle/10722/147101; 55 |
| DOI: |
10.1007/s00125-011-2370-7 |
| Availability: |
https://hub.hku.hk/handle/10722/147101; https://doi.org/10.1007/s00125-011-2370-7; http://www.springerlink.com/link-out/?id=2104&code=W2364W4664351657&MUD=MP |
| Rights: |
The Author(s) ; This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.5B2CDA16 |
| Database: |
BASE |