| Title: |
Profiling cognitive–motor interference in a large sample of persons with progressive multiple sclerosis and impaired processing speed: results from the CogEx study |
| Authors: |
Veldkamp, R; D'hooge, M; Sandroff, BM; DeLuca, J; Kos, D; Salter, A; Feinstein, A; Amato, MP; Brichetto, G; Chataway, J; Farrell, R; Chiaravalloti, ND; Dalgas, U; Filippi, M; Freeman, J; Motl, RW; Meza, C; Inglese, M; Rocca, MA; Cutter, G; Feys, P; CogEx, Res Team |
| Source: |
Journal of Neurology , 270 pp. 3120-3128. (2023) |
| Publisher Information: |
SPRINGER HEIDELBERG |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Clinical Neurology; Neurosciences & Neurology; Multiple sclerosis; Progressive; Cognitive-motor interference; Dual task; Gait; DUAL-TASK-COST; FALL RISK; WALKING; BALANCE; PERFORMANCE; THINKING; TALKING; PEOPLE |
| Description: |
Background: Performing cognitive–motor dual tasks (DTs) may result in reduced walking speed and cognitive performance. The effect in persons with progressive multiple sclerosis (pwPMS) having cognitive dysfunction is unknown. Objective: To profile DT-performance during walking in cognitively impaired pwPMS and examine DT-performance by disability level. Methods: Secondary analyses were conducted on baseline data from the CogEx-study. Participants, enrolled with Symbol Digit Modalities Test 1.282 standard deviations below normative value, performed a cognitive single task ([ST], alternating alphabet), motor ST (walking) and DT (both). Outcomes were number of correct answers on the alternating alphabet task, walking speed, and DT-cost (DTC: decline in performance relative to the ST). Outcomes were compared between EDSS subgroups (≤ 4, 4.5–5.5, ≥ 6). Spearman correlations were conducted between the DTCmotor with clinical measures. Adjusted significance level was 0.01. Results: Overall, participants (n = 307) walked slower and had fewer correct answers on the DT versus ST (both p < 0.001), with a DTCmotor of 15.8% and DTCcognitive of 2.7%. All three subgroups walked slower during the DT versus ST, with DTCmotor different from zero (p’s < 0.001). Only the EDSS ≥ 6 group had fewer correct answers on the DT versus ST (p < 0.001), but the DTCcognitive did not differ from zero for any of the groups (p ≥ 0.039). Conclusion: Dual tasking substantially affects walking performance in cognitively impaired pwPMS, to a similar degree for EDSS subgroups. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10173648/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10173648/1/Chataway_CMI%20in%20PMS%20-%20accepted%20author%20version.pdf; https://discovery.ucl.ac.uk/id/eprint/10173648/ |
| Rights: |
open |
| Accession Number: |
edsbas.5B2E2674 |
| Database: |
BASE |