| Title: |
P-333 Thin endometrium, randomised clinical trial using plasma rich in growth factors |
| Authors: |
Castells, I; Quintana, F; Matorras, R; Fernandez, G; De la Fuente, M; Ferrando, M |
| Source: |
Human Reproduction ; volume 38, issue Supplement_1 ; ISSN 0268-1161 1460-2350 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Study question Does the use of platelet growth factors instilled into thin endometrium in oestrogen-replacement treatment cycles improve endometrial thickness? Summary answer The use of growth factors in thin endometrium improves endometrial growth What is known already Thin endometrium impairs implantation rates and IVF outcomes. To date there is no effective treatment to improve the proliferation. PRGF-Endoret is used in multiple clinical indications. The autologous collection of growth factors (PRGF), applied to the area to be treated, produces a controlled release of multiple molecules with regenerative capacity in the focus of the lesion. Study design, size, duration Prospective randomised clinical trial to determine the effects of PRGF-ENDORET therapy in patients with thin endometrium undergoing oestrogen treatment for embryo transfer. Twenty-two patients were included from March 2018 to May 2021. At the end of the trial, a complementary retrospective study was conducted analysing all the treatments of these patients without live birth(21) before and after participating in the study until December 2022. 15 embryotransfer in study group and 27 in control group. Participants/materials, setting, methods Patients of IVI Bilbao clinic with endometrium less than or equal to 5mm after 10 days of treatment. PRGF was prepared according to the PRGF-Endoret technique using the medical device developed by BTI Biotechnology Institute. The study group received three instillations of PRGF Endoret using a kitazato IUI cannula. The first instillation was performed with in situ activated coagulum and the 2nd and 3rd instillations with PRGF-rich supernatants that were previously stored at -20 °C. Main results and the role of chance The clinical trial showed a significant increase in endometrial thickness 1.3 ± 0.67 mm compared to the control group of 0.58 ± 0.51 mm. Prior to treatment the mean endometrial thickness was 4.29 ± 0.88 in the control group and 4.44 ± 0.40 in the study group. After randomisation the mean ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/humrep/dead093.691 |
| Availability: |
https://doi.org/10.1093/humrep/dead093.691; https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.691/50787408/dead093.691.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.5B6803C0 |
| Database: |
BASE |