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Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry

Title:	Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry
Authors:	Matucci-Cerinic, Marco; Krieg, Thomas; Guillevin, Loic; Schwierin, Barbara; Rosenberg, Daniel; Cornelisse, Peter; Denton, Christopher P; WILLFORT-EHRINGER, A; MONSHI, B; RAFFIER, B; HAFNER, F; KARLHOFER, F; TRAUTINGER, F; BROLL, H; HINTNER, H; JUST, H; KOLLE, H; POPP-HABELER, J; SAUTNER, J; SEMMELWEIS, K; AUSSERWINKLER, M; HIRSCHL, M; HUNDSTORFER, M; KUEN-SPIEGL, M; STETTER, M; TAKACS, M; TOMI, N; MESARIC, P; FELDMANN, R; KNOBLER, R; STROHAL, R; THONHOFER, R; METZ, S; MAURER, B; VERNER, D; DISTLER, O; SCHMIDT-BOSSHARD, R; JORDAN, S; CHOKCHAMPA, T; SMRZOVA, A; SUCHY, D; ZEMANOVA, I; BOHMOVA, J; VITOVA, J; BORTLIK, L; PROCHAZKOVA, L; NEMEC, P; BECVAR, R; ZAHORA, R; SOUKUP, T; FOJTIK, Z; BARATAY, A; BOECKER, A; BRAND, A; DE DONNO, A; DELFS, A; FUNKERT, A; GAUSE, A; GAWLIK, A; GERBER, A; HALLECKER, A; HAZENBILLER, A; HIMSEL, A; HOFFMANN, A; KACZMARCZYK, A; KATZEMICH, A; KETTENBACH, A; KRAUSE, A; KREUTER, A; LUNGWITZ, A; MITCHELL, A; NIEDEMEIER, A; SCHWARTING, A; UNHOLZER, A; VON ELLING, A; ALSHEIMER, B; BELLONI, B; HELLMICH, B; HILDEBRANDT, B; HUETTIG, B; KROG, B; LAUTERWEIN, B; MERK, B; NÜTZEL, B; RABE, B; VOSS, B; WILLIG, B; BAUMANN, C; BEYER, C; ERFURT-BERGE, C; GUENTHER, C; HALLERMANN, C; HILLEBRECHT, C; KELLNER, C; KNEITZ, C; LOEFFLER, C; LUCKGENS, C; MENSING, C; METZLER, C; MUEGLICH, C; NIELEN, C; PFEIFFER, C; PFOEHLER, C; RASCHE, C; RUMBAUR, C; SCHAEFER, C; SUNDERKÖTTER, C; TIGGES, C; ULLRICH GUENTHER, C; VON BORMANN-ALTMEYER, C; WESSEL, C; BORO, D; DILL-MÜLLER, D; DRAGUN, D; MAY, D; MORITZ, D; SCHOEFFEL, D; DREXLER, E; GENTH, E; GERNOT SCHEIBL, E; KAMPE-JUZAK, E; KLEIN, E; KRUPP, E; RICHTER, E; WEISS, E; WÖLLERSDORFER, E; BRAUN, F; DEININGER, F; HARTMANN, F; HELDMANN, F; MOOSIG, F; SADEGHLAR, F; SCHUCH, F; ASSMANN, G; FIERLBECK, G; HALLER, G; HERMANNS, G; MESSER, G; NEECK, G; RIEMEKASTEN, G; BRAND, H; BUEHRE, H; FAUSER, H; KORBER, H; LANGER, H; MENSING, H; RUMPEL, H; SCHLEENBECKER, H; STARZ, H; WAHN, H; WERNITZSCH, H; BLOCHING, HH; LEE, H-H; KLEINER, H-J; TONY, H-P; WILHELM, HU; BOESENBERG, I; FEDEROW, I; FELL, I; FOELDVARI, I; GUERTLER, I; HERRGOTT, I; WUERZBURG, I; ANDRESEN, J; BLUME, J; BÖHM, J; DISTLER, J; DYBALLA, J; EBEL, J; GEORGI, J; GUENZEL, J; HAENTSCH, J; HERING, J; KIRSCHKE, J; MARX, J; NORGAUER, J; OLTMANN SCHROEDER, J; PETERS, J; PFLUGFELDER, J; RUSCHENBURG, J; SCHOLZ, J; SCHUSTER, J; TAGGESELLE, J; VON OELHAFEN, J; VOSWINKEL, J; WELZEL, J; WASMUTH, J-C; SAAL, J-G; KRAUSE, J-O; AHMADI, K; DEUSCHLE, K; HAHN, K; JAHNKE, K; JOERG, K; KNOEBEL, K; KREMER, K; LUETHKE, K; MANGER, K; MATTAT, K; NIEFANGER, K; PLAUMANN, K; SCHATTON, K; SCHILDT, K; SCHMIDT, K; SCHNEIDER, K; SCHULZE, K; SCHWEDA, K; STEINBRINK, K; STORCK-MUELLER, K; GÖTTL, K-H; BRUCKNER, L; MAYER, L; MEIER, L; SCHULTZ, L; TROG, L; BECKER, M; ENDERLEIN, M; FIENE, M; GAUBITZ, M; HAUST, M; HELD, M; KAYSER, M; KOCH, M; LINKE, M; MEGAHED, M; MIFTARAJ, M; MITTAG, M; MONSHAUSEN, M; OELSNER, M; PLEIMES, M; PODDA, M; PODOBINSKA, M; ROBAKIDZE-TORBAHN, M; SARDY, M; SCHMIDT, M; SCHWUERZER-VOIT, M; SEIDEL, M; SEMMLER, M; STICHERLING, M; WITTNER, M; WLODARZ, M; WORM, M; ZABEL, M; ZIAI, M; WERTHMANN, M-L; BLANK, N; DEPPERMANN, N; REISCHEL, N; SCHUETZ, N; SHEIK, N; SHEIKH, N; WAGNER, N; HOFF, N-P; ARIES, P; EILBACHER, P; FREY, P; KARAENKE, P; KAUFMANN, P; MARINA, P; MOINZADEH, P; RAPP, P; SAAR, P; SCHLIMMER, P; VON BILDERLING, PB; FEIK, R; FISCHER-BETZ, R; GLAESER, R; HASSEL, R; HEIN, R; HOLL, R; HUEGEL, R; KURTHEN, R; MERKERT, R; MOTA, R; REEMTSEN, R; ZEUNER, R; ZUPER, R; AKANAY-DIESEL, S; BARTH, S; BLASCHKE, S; CHROMIK, S; DIETL, S; HAPKA, S; HELMUT E, S; JANSCHE, S; KAHL, S; KERN, S; KIRCHBERG, S; KRUSE, S; KUNZE, S; LUPASCHKO, S; METTLER, S; NEUL, S; SCHANZ, S; SCHNARR, S; SPERLING, S; TOELLER, S; ZWENGER, S; KRIEG, T; MARQUARDT, T; MENGDEN, T; RAUEN, T; SCHMEISER, T; SCHUART, T; SEHR, T; STEIN, T; HENKEMEIER, U; HERR, U; KAEDING, U; MEIER, U; MÜLLER-LADNER, U; RIEMENSPERGER, U; RUSHENTSOVA, U; BEKOU, V; NICHELMANN, V; BERG, W; FLAIG, W; HARMUTH, W; OCHS, W; SCHULZ, W; ILLMER, X; FRAMBACH, Y; OLESEN, A; NEUMANN ANDERSEN, G; KNUDSEN, JB; SONDERGAARD, KH; IVERSEN, LV; MOGENSEN, M; GOMMESEN, P; KARLSMARK, T; NADERI, Y; ARAGON, A; CARRO, A; CRUZ, A; GARCIA, A; LOZANO, A; MERA, A; PROS, A; RIVERA, A; RODRIGUEZ DE LA SERNA, A; RUEDA, A; SANCHEZ-ANDRADE FERNANDEZ, A; SANDOVAL, AA; DEL RIO, AH; SANCHEZ ATRIO, AI; CONEJERO, AM; MARHUENDA, AR; MENDOZA, AZ; LOPEZ, B; RAMOS, B; SOPENA, B; BARCA, BA; DE LA CRUZ TAPLADOR, C; DE LA PUENTE, C; FERNANDEZ, C; SIMEON, CP; LAURIN, CU; BELLIDO, D; DE RAMON, E; DELGADO, EG; CORTINA, EL; AIZPURU, EMF; PAMPIN, EP; RABANEDA, EV; GINES MARTINEZ, F; MACEIRAS, F; MEDINA, F; LOPEZ LONGO, FJ; MATEO, FJN; ESPINOSA, G; NICOLAS, GM; CASTELLVI, I; MARTIN, I; MATEO BERNARDO, I; MONTES, IC; BARBADO, J; CRUZ, J; DEL PINO, J; FERNANDEZ, J; MONTES, J; MUNOZ, J; PEGO, J; SANCHEZ, J; USON, J; ZUBIETA, J; CARRASCO, JA; MOSQUERA, JA; TODOLI, JA; FILLOY, JAM; CALVO, JAMIE; TASENDE, JAP; CALVO, JAVIER; DIAZ LOPEZ, JB; MEJIA, JC; LOPEZ, JCF; GIL, JG; ALEGRE SANCHO, JJ; ALONSO, JJ; DIAZ, JJ; PEREZ, JJ; BLANCO, JJR; CALLEJAS, JL; VAZQUEZ, JLG; MASCARO, JM; SABIO, JM; CALABUIG, JR; IVORRA, JR; LARRANAGA, JR; MANEIRO, JR; BLANCO, JS; COLEMAN, JV; GONZALEZ HOMBRADO, L; LOSADA, L; SAEZ, L; ALPERI LOPEZ, M; ANGELES AQUIRRE, M; CORTEGUERA, M; CRESPO, M; DEL CARMEN FREIRE, M; DEL CARMEN ORTEGA DE LA O, M; DEL CARMEN TORRES MARTIN, M; DEL MAR RIPOLL MACIAS, M; FREIRE GONZALEZ, M; MONTORO ÁLVAREZ, M; RAMOS, M; RUBIO, M; EGURBIDE, M VICTORIA; YEBRA, M; ABAD HERNANDEZ, MA; RODRIGUEZ, MAP; FITO MANTECA, MC; SANCHEZ, MDM; HERNAN, MGB; CAAMANO, ML; GONZALEZ GONZALEZ, ML; HUERTAS, MP; SANTO, MP; DEL CASTILLO, MR; LOPEZ, MR; TRENADO, MSS; CAMPS, MT; ORTEGO, N; FERNANDEZ, NC; BECERRA, ND; NAVAJAS, P; DELGADO, PC; RAMOS, PC; DEL LA PENA LEFEBVRE, PG; ALONSO, PN; SANCHEZ, PS; GARCIA, P-V; MIGUELEZ, R; PEREZ, R; DE LA TORRE, RG; DE VICUNA, RG; INSUA, S ANTONIO; FERNANDEZ, S; SANDOVAL, TP; RODRIGUEZ, TRV; VILLAVERDE, V; MANZANEDO, VS; KAARTO, A; MAKINEN, H; KARSTILA, K; VIDQVIST, K-L; LOUSIJÄRVI, R; BEREZNE, A; COURAUD, A; DADBAN, A; HOT, A; KANOTE, A; KHAU VAN KIEN, A; LE QUELLEC, A; LETREMY, A; PERLAT, A; RAMASSAMY, A; SPARSA, A; TAIEB, A; ZOULIM, A; DUVAL-MODESTE, A-B; CHAIGNEAU, A-F; FAUCHAIS, A-L; COPPERE, B; COURET, B; GRAFFIN, B; GRANEL, B; IMBERT, B; SASSOLAS, B; AGARD, C; BELIZNA, C; BOULON, C; CAZALETS-LACOSTE, C; DIVOY, C; DROITCOURT, C; DURANT, C; FARCAS, C; FRANCES, C; GRANGE, C; LANDRON, C; LE CLECH, C; LOK, C; NADÈGE, C; RICHEZ, C; SORDET, C; TOLEDANO, C; ADOUE, D; BARCAT, D; BESSIS, D; CHICINAS-BICA, D; FARGE, D; FERRANDIZ, D; LAUNAY, D; WAHL, D; BELIN, E; BERNIT, E; CHATELUS, E; COLLET, E; DIOT, E; HACHULLA, E; KOSTRZEWA, E; PASQUALONI, E; TRUCHETET, E; VIDAL, E; WIERZBICKA-HAINAUT, E; DUCHENE, F; GACHES, F; GRANEL-BROCARD, F; MAURIER, F; SKOWRON, F; BLAISON, G; GOUDRAN, G; KAPLANSKI, G; MOULIS, G; MULLER, G; PUGNET, G; WOJTASIK, G; ADAMSKI, H; BEZANAHARY, H; CHARLANNE, H; CHIFFLOT, H; DESMURS-CLAVEL, H; GIL, H; KESHTMAND, H; MAILLARD, H; LAZARETH, I; QUÉRÉ, I; NICOL, IM; BOILEAU, J; CABANE, J; CHEVRANT-BRETON, J; CONSTANS, J; NINET, J; SÉNÉSCHAL, J; SIBILIA, J; WIPFF, J; COHEN, JD; VIALLARD, J-F; FUZIBET, JG; DURAND, JM; BALDUCCHI, J-P; ORY, JP; HARLE, J-R; MAZODIER, K; TALOUR, K; TIEV, K; BLUM, L; GUILLEVIN, L; MISERY, L; MOUTHON, L; PERARD, L; SAILLER, L; DANDURAND, M; DINULESCU, M; GRECO, M; LAMBERT, M; SEVESTRE, M; DIANCOURT, M-H; GIRARD-MADOUX, M-H; CHAUVEHEID, M-P; MOITON, M-P; DOUTRE, M-S; ASSOUS, N; BENETON, N; BOUSSELY, N; JOURDAIN, N; MAGY-BERTRAND, N; SCHLEINITZ, N; CARTRY, O; DEBOVES, O; DECAUX, O; BACHET, P; CARPENTIER, P; JEGO, P; MANEA, P; POUBEAU, P; PRIOLLET, P; ROBLOT, P; RULLIER, P; HATRON, P-Y; FERREIRA, R; JEAN, R; AGNES, S; BERTHIER, S; BLAISE, S; BLAQUIERE, S; DUMONTEIL, S; DUPAS, S; HESSE, S; MADAULE, S; MORELL, S; PREY, S; RIVIERE, S; SKOPINSKI, S; ZUILY, S; MARTIN, T; MOLINE, T; QUEMENEUR, T; ZENONE, T; MICHON-PASTUREL, U; BRAVETTI, V; CANNIEUX, V; DOEFFEL-HANTZ, V; LEGUY-SEGUIN, V; LOUSTAUD-RATTI, V; QUEYREL, V; KYNDT, X; ALLANORE, Y; LEVENEUR, Y; REGUIAI, Z; ELEZOGLOU, A; GARYFALLOS, A; KOUTROUMBAS, A; ZAHARIOUDAKI, A; DROSOS, AA; HARALAMBOS, B; DIMOPOULOU, D; MPASDAGIANNI, D; VASILOPOULOS, D; KALTSONOUDIS, E; VEGOUDAKI, G; GKOUGKOURELAS, I; KRITIKOS, I; MICHAILIDOU, M; GALANOPOULOS, N; PAPADOPOULOS, N; TSIFETAKI, N; ATHANASSIOU, P; VLACHOYANNOPOULOS, P; ASLANIDIS, S; KAMALI, S; DIMITROULAS, T; GALANOPOULOU, V; GRIER, A; VEALE, D; O'ROURKE, M; AMOROSO, A; BENENATI, A; BORTOLUZZI, A; CORRADO, A; DELLA ROSSA, A; GABRIELLI, A; GIARDINA, A; MATHIEU, A; MAZZONE, A; MUSSI, A; NIGRO, A; SEVERINO, A; VACCA, A; CAPUANO, B; MARASINI, B; BOSELLO, C; FERRI, C; LUNARDI, C; SALVARANI, C; SELMI, C; MONTECUCCO, CM; GIUGGIOLI, D; BATTAGLIA, E; FUSARO, E; ROSATO, E; BELLISAI, F; CANTATORE, F; COZZI, F; DALL’ARA, F; GALLUCCIO, F; PUPPO, F; SALSANO, F; TROTTA, F; BAJOCCHI, G; CUOMO, G; FERRACCIOLI, G; LAPADULA, G; PATUZZO, G; POMPONIO, G; TRIOLO, G; VALENTINI, G; VALESINI, G; VARCASIA, G; CHIAROLANZA, I; DI DONATO, I; OLIVIERI, I; BELLOLI, L; BERETTA, L; COLONNA, L; SERAFINO, L; ANTIVALLE, M; BATTELINO, M; BORSETTO, M; BRUZZONE, M; COLACI, M; DE MATTIA, M; DE SANTIS, M; DOVERI, M; GALEAZZI, M; MATUCCI CERINIC, M; MOSCA, M; RIZZO, M; SARACCO, M; VASILE, M; DEL PAPA, N; MALAVOLTA, N; TERLIZZI, N; UGHI, N; AIRO, P; CIPRIANI, P; FAGGIOLI, P; MASOLINI, P; RUSCITTI, P; BUCCI, R; CARIGNOLA, R; CIMINO, R; DE ANGELI, R; FOTI, R; GIACOMELLI, R; LA CORTE, R; MULE, R; PELLERITO, R; PERRICONE, R; SCORZA, R; BELLISSIMO, S; BOMBARDIERI, S; DE VITA, S; GATTI, S; LOMBARDI, S; MAZZUCA, S; NEGRINI, S; PALLOTTA, S; PARISI, S; STISI, S; TRINCONE, S; ZENI, S; ZINGARELLI, S; CARRARO, V; CODULLO, V; RICCIERI, V; GRASSI, W; MAGLIONE, W; SPOORENBERG, A; SCHOUFFOER, AA; HAK, AE; VAN DEN BIJL, AE; VOSKUYL, AE; GERARDS, AH; HEURKENS, AHM; PEETERS, AJ; SMIT, AJ; SWAAK, AJG; DE JONG, AJL; SCHUERWEGH, AJM; NAAFS, B; BIJKERK, C; VAN DURME, C; VAN GULDENER, C; LEBRUN, CEI; DEN HENGST, CW; SIEWERTSZ VAN REESEMA, D; VAN ZEBEN, D; KUIPER-GEERTSMA, DG; MULDER, DJ; SIEWERTSZ VAN REESEMA, DR; KNIJFF-DUTMER, E; TON, E; STROES, ESG; BONTE-MINEUR, F; EGGELMEIJER, F; UBELS, F; VAN DEN HOOGEN, FHJ; VAN NEER, FJMA; BRUIJN, G; BRUYN, GAW; VAN VEEN, GJM; BOOTSMA, H; HOUBEN, H; HULSMANS, H; RONDAY, H; VAN PAASSEN, H; VISSER, H; KAASJAGER, HAH; KNAAPEN, HKA; WILLEMS, HPJ; SPEYER, I; VAN GAMEREN, I; FELIUS, ID; EWALS, J; GROENENDAEL, J; HAVERMAN, J; MOOLENBURGH, JD; GROENENDAEL, JHLM; VAN WOERKOM, JM; STOLK, JN; HAN, KH; BROUWER, L; RAMAKERS, LINSSEN-; BIJL, M; DE BOIS, M; JANSSEN, M; NOORDZIJ, M; VAN KRUGTEN, M; VLOEDBELD, M; WALRAVENS, M; VAN DE REE, MA; DE KANTER, MAE; GEURTS, MAW; VONK, MC; JEURISSEN, MEC; VAN DER VEEN, MJ; WESTEDT, ML; VAN BRUSSEL, MS; MOLDERS, N; BAUDOIN, P; FRETTER, P; SEYS, P; VAN DER LUBBE, P; VAN PAASSEN, P; VOS, PAJM; DE SONNAVILLE, PBJ; REMANS, PH; JACOBS, PJC; LANTING, PJH; VAN DAELE, PLA; HOUTMAN, PM; VAN HAGEN, PM; GOEKOOP, R; VALENTIJN, R; WESTRA, R; LANDEWE, RBM; DOLHAIN, RJEM; LEMSON, S; HURKENS, T; JANSEN, T; ZIJLSTRA, TR; HUIZINGA, TWJ; GERDES, VEA; HISSINK MULLER, W; VERCOUTERE, W; DE BEUS, WM; JAHANGIER DE VEEN, ZN; BENDVOLD, A; HOFFMANN-VOLD, A-M; GRANDAUNET, B; NORDVAG, B-Y; GJESDAL, CG; STRAND, EK; BAKLAND, G; KORNELUK-THOR, G; BITTER, H; ASLAKSEN, HK; SKOMSVOLL, J; SEIP, M; MIDTVEDT, O; THOMSEN, RS; KALSTAD, S; PEDERSEN, T; MADLAND, TM; BAKKEHEIM, V; KOLDINGSNES, W; CORDEIRO, A; GRiLO, A; RODRIGUES, AC; PONTE, C; RESENDE, C; SANTOS, C; SILVA, F; ALMEIDA, I; CAMARA, I; SILVA, I; ALVES, J; COSTA, J; OLIVEIRA, M; RISO, N; COELHO, P; FERREIRA, PA; OLIVEIRA, S; HOLMSTRAND, A; MOHAMMAD, A; NORDIN, A; OSTENSON, A; MOLLER, B; HALLENGREN, C STAHL; THORSSON, C; HERMANSSON, E; LILJEQUIST, E; WALDHEIM, E; ABDIU, G; HELLSTROM, H; KLASSON, J; ALBERTSSON, K; LIND, K; VENGEMYR, K; HEMBERG, M; RIZK, M; SODERLIN, M; TEGMARK, S; BRACIN, T; VINGREN, T; WEITOFT, T; RYDVALD, Y; FABIENNE, Z; DOLNICAR, AS; LUKAC, J; ÖETTEROVA, M; KILLINGER, Z; KMECOVA, Z; MACEJOVA, Z; FAIZAL, A; HERRICK, A; MORRIS, A; SINHA, A; SMYTH, A; WHITE-ALAO, B; BAINES, C; CHATTOPADHYAY, C; DENTON, C; MORRISON, C; TAYLOR, C; WILLIAMS, C; D'CRUZ, D; SWIFT, D; TILLEY, D; WRAGG, E; ABDUL, F; HALL, F; ABIGNANO, G; HARRIS, H; SYKES, H; YOUSSEF, HM; YOUSSEF, H; BELCH, J; COPPOCK, J; DOBSON, J; WYKES, J; MURPHY, K; NADESALINGAM, K; PARKER, L; CHOONG, LM; AKIL, M; ANDERSON, M; BUCH, M; NISAR, M; ROWAN, M; MCHUGH, N; ATHIVEER, P; GORDON, P; MADHOK, R; MOOTS, R; OCHIEL, R; SALERNO, R; VINCENT, R; ARTHANARI, S; BROWN, S; DUBEY, S; JARRETT, S; MCSWIGGAN, S; CHAHAL, S PARVINDER; SKINGLE, S; ZIMBA, S; XU, Y
Contributors:	Matucci-Cerinic, Marco; Krieg, Thoma; Guillevin, Loic; Schwierin, Barbara; Rosenberg, Daniel; Cornelisse, Peter; Denton, Christopher P; WILLFORT-EHRINGER, A; Monshi, B; Raffier, B; Hafner, F; Karlhofer, F; Trautinger, F; Broll, H; Hintner, H; Just, H; Kolle, H; POPP-HABELER, J; Sautner, J; Semmelweis, K; Ausserwinkler, M; Hirschl, M; Hundstorfer, M; KUEN-SPIEGL, M; Stetter, M; Takacs, M; Tomi, N; Mesaric, P; Feldmann, R; Knobler, R; Strohal, R; Thonhofer, R; Metz, S; Maurer, B; Verner, D; Distler, O; SCHMIDT-BOSSHARD, R; Jordan, S; Chokchampa, T; Smrzova, A; Suchy, D; Zemanova, I; Bohmova, J; Vitova, J; Bortlik, L; Prochazkova, L; Nemec, P; Becvar, R; Zahora, R; Soukup, T; Fojtik, Z; Baratay, A; Boecker, A; Brand, A; DE DONNO, A; Delfs, A; Funkert, A; Gause, A; Gawlik, A; Gerber, A; Hallecker, A; Hazenbiller, A; Himsel, A; Hoffmann, A; Kaczmarczyk, A; Katzemich, A; Kettenbach, A; Krause, A; Kreuter, A; Lungwitz, A; Mitchell, A; Niedemeier, A; Schwarting, A; Unholzer, A; VON ELLING, A; Alsheimer, B; Belloni, B; Hellmich, B; Hildebrandt, B; Huettig, B; Krog, B; Lauterwein, B; Merk, B; Nützel, B; Rabe, B; Voss, B; Willig, B; Baumann, C; Beyer, C; ERFURT-BERGE, C; Guenther, C; Hallermann, C; Hillebrecht, C; Kellner, C; Kneitz, C; Loeffler, C; Luckgens, C; Mensing, C; Metzler, C; Mueglich, C
Publisher Information:	BMJ PUBLISHING GROUP; BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
Publication Year:	2016
Collection:	Università degli Studi di Genova: CINECA IRIS
Subject Terms:	Autoimmune Disease; Epidemiology; Systemic Sclerosis
Description:	Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc) and may lead to infection, gangrene and amputation with functional disability and reduced quality of life. This study has elucidated the burden of SSc-associated DUs through identification of four patient categories based on the pattern of DU recurrence over a 2-year observation period.Methods Patients with SSc-associated DUs enrolled in the Digital Ulcers Outcome Registry between 1 April 2008 and 19 November 2013, and with 2years of observation and 3 follow-up visits during the observation period were analysed. Incident DU-associated complications were recorded during follow-up. Work and daily activity impairment were measured using a functional assessment questionnaire completed by patients after the observation period. Potential factors that could predict incident complications were identified in patients with chronic DUs.Results From 1459 patients, four DU occurrence categories were identified: 33.2% no-DU; 9.4% episodic; 46.2% recurrent; 11.2% chronic. During the observation period, patients from the chronic category had the highest rate of incident complications, highest work impairment and greatest need for help compared with the other categories. Independent factors associated with incident complications included gastrointestinal manifestations (OR 3.73, p=0.03) and previous soft tissue infection (OR 5.86, p=0.01).Conclusions This proposed novel categorisation of patients with SSc-associated DUs based on the occurrence of DUs over time may help to identify patients in the clinic with a heavier DU burden who could benefit from more complex management to improve their functioning and quality of life.
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/26612339; info:eu-repo/semantics/altIdentifier/wos/WOS:000384438900016; volume:75; firstpage:1770; lastpage:1776; numberofpages:7; journal:EARD; https://hdl.handle.net/11567/1164040
DOI:	10.1136/annrheumdis-2015-208121
Availability:	https://hdl.handle.net/11567/1164040; https://doi.org/10.1136/annrheumdis-2015-208121
Accession Number:	edsbas.5B7A0CD7
Database:	BASE