| Title: |
Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand |
| Authors: |
Kaestner, L; Egée, S; Connes, P; Bogdanova, AY; Simmonds, MJ |
| Publisher Information: |
National Academy of Sciences |
| Publication Year: |
2025 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Gastroenterology and hepatology |
| Description: |
Splenic filtration of red blood cells (RBCs) is one of the physiological functions that is both fascinating and yet remains somewhat mysterious. During splenic transit, RBCs must rapidly pass sinusoidal slits much smaller than their own dimensions and be effectively sorted and disposed when senescent or damaged. Recently, Moreau et al. presented seminal work combining in vitro experiments and theoretical modeling on the physical mechanisms of RBC splenic filtration (1). While we appreciate the comprehensive physical explanations, we highlight the biological aspects of filtration extend beyond the scope of this paper but remain essential. Specifically, we disagree that mechanosensitive ion channels (e.g., Piezo1) are not vitally involved in splenic transit in vivo, while acknowledging electrophysiological and biochemical properties of RBCs under mechanical stress are complex. We thus provide a counterpoint to present a holistic perspective. ; Full Text |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Proceedings of the National Academy of Sciences; Kaestner, L; Egée, S; Connes, P; Bogdanova, AY; Simmonds, MJ, Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand, Proceedings of the National Academy of Sciences, 2025, 122 (2), pp. e2405086121; https://hdl.handle.net/10072/435388 |
| DOI: |
10.1073/pnas.2405086121 |
| Availability: |
https://hdl.handle.net/10072/435388; https://doi.org/10.1073/pnas.2405086121 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; © 2025 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). ; open access |
| Accession Number: |
edsbas.5B8D9FBB |
| Database: |
BASE |