| Title: |
Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the ‘Women First’ maternal preconception nutrition randomised controlled trial |
| Authors: |
Fernandes, M; Krebs, NF; Westcott, J; Tshefu, A; Lokangaka, A; Bauserman, M; Garcés, AL; Figueroa, L; Saleem, S; Aziz, SA; Goldenberg, RL; Goudar, SS; Dhaded, SM; Derman, RJ; Kemp, JF; Koso-Thomas, M; Sridhar, A; M McClure, E; Hambidge, KM; Group, The Women First Preconception Nutrition Trial Study |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background: Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited. Objectives: To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains. Design: Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial. Setting: Rural Democratic Republic of the Congo, Guatemala, India and Pakistan. Participants: 667 offspring of Women First trial participants, aged 24 months. Intervention: Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery. Main outcome measures: The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates. Results: No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ24), socio-economic status, maternal education and FCI significantly predicted vision and INTER-NDA scores (R2=0.11–0.38, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/archdischild-2023-325352 |
| Availability: |
https://doi.org/10.1136/archdischild-2023-325352; https://ora.ox.ac.uk/objects/uuid:435f9828-280d-4a68-908a-74e71c5ca850 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.5BA09F08 |
| Database: |
BASE |