| Title: |
Gender Differences in the Association of Neutrophil Gelatinase‐Associated Lipocalin with Cognitive Impairment and Depression in Heart Failure |
| Authors: |
Schoemaker, Regien G; Gouweleeuw, Leonie; Hovens, Iris B; Liu, Hui; Naude, Pieter JW; Eisel, Uli ML |
| Source: |
The FASEB Journal ; volume 30, issue S1 ; ISSN 0892-6638 1530-6860 |
| Publisher Information: |
Wiley |
| Publication Year: |
2016 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Introduction Heart failure increases the risk to develop depression, which worsens prognosis. Depression is more common in women than in men. Neutrophil Gelatinase‐Associated Lipocalin (NGAL), a regulator of inflammation and indicator of prognosis in heart failure patients, is also associated with depression. The aim of this study was to investigate the association of NGAL with behavior in both male and female rats with heart failure. Methods Male and female Wistar rats were subjected to coronary artery ligation (MI) or sham surgery. Three weeks later, depressive symptoms were obtained from the open field test (OF) and cognitive functioning from the novel object and novel location test. Plasma levels of NGAL were measured with Elisa, and NGAL expression in the brain was obtained using immunohistochemistry. Results In males, but not in females, plasma NGAL appeared correlated to infarct size. We found both a gender (F=6.53, p=0.005) and an MI (F=6.63, p=0.013) effect in plasma NGAL levels, with higher levels in male compared to female rats and MI compared to sham rats. An MI effect (F=4.19, p=0.049) and interaction effect (F=7.87, p=0.09) were found in the number of NGAL positive cells in the paraventricular nucleus of the hypothalamus (PVN), post‐hoc analysis showed that NGAL was elevated only in male rats upon MI. Spatial object recognition was impaired in male MI compared to sham rats (discrimination index 54.3% vs 78.3%, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1096/fasebj.30.1_supplement.993.14 |
| Availability: |
http://dx.doi.org/10.1096/fasebj.30.1_supplement.993.14 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.5BBBAFF |
| Database: |
BASE |