| Title: |
Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients |
| Authors: |
Pare, Rahmawati (S31242); Soon, Patsy S.; Shah, Aashit; Lee, Cheok Soon (R13259) |
| Contributors: |
School of Medicine (Host institution) |
| Publisher Information: |
U.S., Public Library of Science |
| Publication Year: |
2019 |
| Collection: |
University of Western Sydney (UWS): Research Direct |
| Subject Terms: |
XXXXXX - Unknown; breast; cancer; histology; pathological |
| Description: |
Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combined marker with P16 or P14 using breast cancer progression series. One thousand and eighty (1080) patients with primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective study period. We constructed tissue microarrays of normal, benign hyperplasia, ductal carcinoma in situ and invasive ductal carcinoma from each patient and performed immunohistochemical staining to study the protein expression. Statistical analysis includes Pearson chi-square, Kaplan-Meier log ran test and Cox proportional hazard regression were undertaken to determine the associations and predict the survival outcomes. P53, DEC1 and DCR2 expression correlated significantly with normal, benign, premalignant and malignant tissues with (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
print |
| Language: |
English |
| Relation: |
PLoS One--1932-6203 Vol. 14 Issue. 4 No. e0214604 |
| DOI: |
10.1371/journal.pone.0214604 |
| Availability: |
https://doi.org/10.1371/journal.pone.0214604; http://handle.westernsydney.edu.au:8081/1959.7/uws:51078 |
| Rights: |
© 2019 Pare et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Accession Number: |
edsbas.5BBEAC8B |
| Database: |
BASE |