| Title: |
Flash Communication: Visible-Light-Driven, Cobalt-Mediated Selective C–H Arylation of 2,2′-Bipyridine |
| Authors: |
Xi Chen; Eric R. Allen; McKenzie L. Stack; Zachary M. Garozzo; Dian Wang |
| Publication Year: |
2025 |
| Collection: |
Erasmus University Rotterdam (EUR): Figshare |
| Subject Terms: |
Microbiology; Ecology; Infectious Diseases; Chemical Sciences not elsewhere classified; widely used class; transition metal catalysis; method employs cost; excellent c6 selectivity; bpy )< sub; electronically varied 6; 2 ′- bipyridine; pure form; provides one; previous work; mild conditions; joint action; flash communication; enabling arylation; effective reagents; direct access; broad range; ancillary ligands |
| Description: |
Herein, we report a visible-light-driven, cobalt-mediated, highly selective C–H arylation method to afford aryl-2,2′-bipyridine, a widely used class of ancillary ligands in transition metal catalysis. This arylation reaction exhibits good-to-excellent C6 selectivity for a variety of aryl groups, allowing for isolation of the 6-isomer in its pure form. Mechanistic studies provided evidence for the generation of an aryl radical by the joint action of [Co(bpy) 3 ] species and visible light, enabling arylation under mild conditions. Compared to previous work, this method employs cost-effective reagents and provides one-step, direct access from 2,2′-bipyridine to a broad range of electronically varied 6-aryl-2,2′-bipyridine products. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1021/acs.organomet.5c00204.s001 |
| Availability: |
https://doi.org/10.1021/acs.organomet.5c00204.s001; https://figshare.com/articles/journal_contribution/Flash_Communication_Visible-Light-Driven_Cobalt-Mediated_Selective_C_H_Arylation_of_2_2_-Bipyridine/29802854 |
| Rights: |
CC BY-NC 4.0 |
| Accession Number: |
edsbas.5BEAB567 |
| Database: |
BASE |