| Title: |
Journal of Allergy and Clinical Immunology / Monitoring the epitope recognition profiles of IgE, IgG(1), and IgG(4) during birch pollen immunotherapy |
| Authors: |
Gepp, Barbara; Lengger, Nina; Moebs, Christian; Pfuetzner, Wolfgang; Radauer, Christian; Bohle, Barbara; Breiteneder, Heimo |
| Publisher Information: |
Elsevier |
| Publication Year: |
2016 |
| Collection: |
MedUni Vienna ePub (Medzinische Universität Wien) |
| Subject Terms: |
bet v 1; oral immunotherapy; allergen; responses |
| Subject Geographic: |
UMW:14528 |
| Description: |
It is well established that allergen-specific IgG antibodies induced during allergen-specific immunotherapy (AIT) can block the IgE-mediated cascade of allergic inflammation.1 Although this role of IgG has been intensively studied, little is known about the epitope diversities of immunoglobulin subclasses induced during AIT. Thus far, analyses of IgG4-binding patterns to major cow's milk2 and peanut3 allergens during oral AIT revealed discrepant results. The overall diversity of IgG4 specific for cow's milk allergens changed little,2 whereas the IgG4 repertoire specific for peanut allergens was broadly expanded in a polyclonal fashion, including de novo–generated specificities different from IgE. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0091-6749 |
| Relation: |
vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-1712/128; local:99144872269603331; system:AC15253934 |
| DOI: |
10.1016/j.jaci.2015.10.022 |
| Availability: |
https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-1712; https://doi.org/10.1016/j.jaci.2015.10.022; https://repositorium.meduniwien.ac.at/doi/10.1016/j.jaci.2015.10.022 |
| Rights: |
CC BY-NC-ND 4.0 |
| Accession Number: |
edsbas.5BFB3EC0 |
| Database: |
BASE |