| Title: |
Long-Term Effects of Direct-Acting Antivirals on Hepatitis C: Trends in Liver Disease-Related Hospitalisations in Italy |
| Authors: |
Mennini FS; Sciattella P; Simonelli C; Marcellusi A; Rosato S; Kondili LA. |
| Contributors: |
F. Mennini; P. Sciattella; C. Simonelli; A. Marcellusi; S. Rosato; L. Kondili |
| Publisher Information: |
Wiley Blackwell Publishing |
| Publication Year: |
2025 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
alcohol; chronic hepatitis C; cirrhosi; hepatocellular carcinoma; Settore CHEM-08/A - Tecnologia; socioeconomia e normativa dei medicinali e dei prodotti per il benessere e per la salute |
| Description: |
This study aimed to evaluate the effectiveness of direct-acting antivirals (DAAs) on hepatitis C virus (HCV) hospitalisation trends in Italy, the country with not only the highest burden of HCV-related disease but also the highest number of patients treated for chronic HCV infection in Europe. Incident hospital discharge records in Italy from 2012 to 2019 that included a liver cirrhosis diagnosis without mention of alcohol, hepatocellular carcinoma (HCC), HCV and liver cirrhosis without mention of alcohol and/or HCC, cirrhosis with mention of alcohol, as defined by the International Classification of Diseases (ICD-9-CM) were reviewed. An interrupted time series analysis compared the incidence of cirrhosis and HCC before and after the introduction of DAAs (Year 2015). Overall, non-alcoholic cirrhosis significantly decreased after the introduction of DAAs (β3 = 0.03) and for those 40–59 years of age (β3 = 0.025). HCV with cirrhosis and/or HCC significantly reduced overall for those aged 40–59 and older than 60 ((Formula presented.)). HCC-related hospitalisation rates significantly decreased in patients younger than 60 ((Formula presented.)). Cirrhosis-related hospitalisations with mention of alcohol did not differ during the study period before and after the year 2015 ((Formula presented.)). There was a significant reduction in HCV-related hospitalisations throughout Italy after introducing DAAs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39868676; info:eu-repo/semantics/altIdentifier/wos/WOS:001406161800001; volume:32; issue:2; firstpage:1; lastpage:13; numberofpages:13; journal:JOURNAL OF VIRAL HEPATITIS; https://hdl.handle.net/2434/1158484 |
| DOI: |
10.1111/jvh.14061 |
| Availability: |
https://hdl.handle.net/2434/1158484; https://doi.org/10.1111/jvh.14061 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.5BFC9D0 |
| Database: |
BASE |