| Title: |
Supervised Injecting Room Cohort Study (SIRX): study protocol |
| Authors: |
Stewart, AC; Hickman, M; Agius, PA; Scott, N; Stone, J; Roxburgh, A; O’Keefe, D; Higgs, P; Kerr, T; Stoové, MA; Thompson, A; Crawford, S; Norman, J; Vella-Horne, D; Lloyd, Z; Clark, N; Maher, L; Dietze, P |
| Publisher Information: |
BMJ |
| Publication Year: |
2025 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Supervised injecting facilities (SIFs) are designed to reduce the harms associated with injecting drug use and improve access to health and support services for people who need them. The Supervised Injecting Room Cohort Study (SIRX) aims to provide evidence of the effects, including cost-effectiveness, of a SIF embedded within a community health service, the Melbourne Medically Supervised Injecting Room (MSIR), which has a range of integrated harm reduction, health and social support services on-site. METHODS AND ANALYSIS: The SIRX study design involves two prospective cohort studies that collect behavioural data and retrospectively and prospectively linked administrative data for primary and tertiary health services, criminal justice records, and mortality. The two cohorts are: (1) participants drawn from the existing Melbourne Injecting Drug User Cohort Study (SuperMIX; established in 2008-ongoing) through which participants consent to annual behavioural surveys (including serological testing for HIV and hepatitis B and C viruses) and linkage to administrative data; and (2) the SIRX-Registration Cohort (SIRX-R; established in 2024) comprising registered MSIR clients who consent to a baseline behavioural survey and administrative data linkage including the frequency of SIF use, and the uptake of on-site services. Primary outcomes are aligned to the legislated aims of the Melbourne MSIR, including ambulance-attended non-fatal overdoses and all-cause and drug-related mortality. Using causal inference methods, analyses will estimate the effect of MSIR exposure (frequent use/infrequent use/no use) on these primary outcomes. The SIRX study also has a secondary focus on the effect of MSIR exposure on health service use and related outcomes. ETHICS AND DISSEMINATION: SuperMIX Study (599/21) and SIRX-R Study (71/23) ethics approvals were obtained from Alfred Hospital Research Ethics Committee. Participants will be assessed for capacity to provide informed consent following a detailed explanation of the ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2044-6055 |
| Relation: |
https://hdl.handle.net/11343/366139 |
| Availability: |
https://hdl.handle.net/11343/366139 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.5C24FFC0 |
| Database: |
BASE |