| Title: |
A new partially hydrolyzed whey-based follow-on formula with age-adapted protein content supports healthy growth during the first year of life |
| Authors: |
Claude Billeaud; Latif Adamon; Hugues Piloquet; Nicholas P. Hays; Lénaïck Dupuis; Isabelle Metreau; André Léké |
| Source: |
Frontiers in Pediatrics, Vol 10 (2022) |
| Publisher Information: |
Frontiers Media S.A. |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
infant formula; follow-on formula; protein; growth; tolerance; partially-hydrolyzed; Pediatrics; RJ1-570 |
| Description: |
BackgroundStandard infant formulae often have higher protein content than breastmilk in order to compensate for potentially lower digestibility; excess protein intake may promote adverse effects later in life. A new partially hydrolyzed whey-based (pHF-W) follow-on formula (FoF) with age-adapted protein content was evaluated for growth and gastrointestinal (GI) tolerance in healthy infants.MethodsFormula-fed (FF) infants (n = 108) received standard pHF-W formula (1.9 g protein/100 kcal) from enrollment (age ≤ 30 days) until age 120 days followed by new pHF-W FoF (1.6 g protein/100 kcal) until 360 days. Weight gain velocity (WGV) (mean daily WG from enrollment to age 180 days) was compared to WHO growth standards and a breastfed (BF) reference group (n = 86) (non-inferiority margin –3 g/day). GI tolerance was assessed using a validated questionnaire (scale range 13−65).ResultsWGV in FF infants (mean ± SD 24.0 ± 4.4 g/day) was non-inferior to BF (23.7 ± 3.9 g/day) and WHO standards (all p ≤ 0.013). Weight-for-age, length-for-age, weight-for-length, and head circumference-for-age z-scores of FF infants were not significantly different from BF at any timepoint. Symptoms of GI intolerance were low (≤23) at all timepoints and similar between groups.ConclusionA new pHF-W FoF with age-adapted protein content fed sequentially after standard pHF-W infant formula is safe, well-tolerated, and promotes a healthy growth pattern consistent with BF infants and WHO standards during the first year of life.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT03276663]. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fped.2022.937882/full; https://doaj.org/toc/2296-2360; https://doaj.org/article/3c292dc6d4b1420e8823b4cfed2318e3 |
| DOI: |
10.3389/fped.2022.937882 |
| Availability: |
https://doi.org/10.3389/fped.2022.937882; https://doaj.org/article/3c292dc6d4b1420e8823b4cfed2318e3 |
| Accession Number: |
edsbas.5C2FC81B |
| Database: |
BASE |