| Title: |
Pre- and post-diagnostic meat intake in relation to risk of recurrence and mortality among individuals with stage I–III colorectal cancer |
| Authors: |
van Lanen,Anne Sophie; Kok,Dieuwertje E.; Wesselink,Evertine; Derksen, Jeroen W.G.; May, Anne M.; Smit, Karel C.; Koopman, Miriam; de Wilt,Johannes H.W.; Kampman,Ellen; van Duijnhoven,Fränzel J.B.; van Cruijsen,Hester; Dekker, Jan Willem T.; van Halteren,Henk K.; Janssen,Johan J.B.; Los, Maartje; Schiphorst,Anandi H.W.; Sommeijer,Dirkje W.; Sonneveld,Dirk J.A.; Sie,Mark P.S.; Vermaas,Maarten; the COLON and PLCRC studies; Epi Kanker Team B; Cancer; Epi Kanker; JC onderzoeksprogramma Cancer; Medisch Oncologische Disciplines; Unit Opleiding Aios; MS Medische Oncologie; Apotheek Bereidingen; MS CGO |
| Publication Year: |
2026 |
| Subject Terms: |
all-cause mortality; colorectal cancer recurrence; processed meat; unprocessed poultry; unprocessed red meat; Oncology; Cancer Research |
| Description: |
Processed meat and unprocessed red meat intakes are associated with increased colorectal cancer (CRC) risk, but evidence on associations with mortality after a CRC diagnosis is inconsistent. To date, no studies examined associations between unprocessed poultry intake and mortality, or assessed cancer recurrence risk as a separate outcome measure. We included data from 2484 individuals, who were newly diagnosed with stage I–III CRC, participating in 2 prospective cohort studies. Dietary intake was assessed at diagnosis and 6 months after diagnosis. Multivariable Cox proportional hazards regression models and restricted cubic splines were used to examine associations between pre- and post-diagnostic meat intake and risk of recurrence and all-cause mortality. We performed subgroup analyses by sex, disease stage and primary tumour location. During a median follow-up time of 5.0 years for recurrence analyses and 6.4 years for mortality analyses, 336 recurrences and 409 deaths occurred. Pre- and post-diagnostic processed meat and unprocessed red meat intakes were not associated with risk of recurrence nor all-cause mortality. At both timepoints, a higher unprocessed poultry intake was non-linearly associated with a decreased mortality risk, with the lowest risk observed at 20 g/day (hazard ratio: 0.63, 95% confidence interval: 0.47–0.85), compared to 0 g/day. Results were not substantially different by sex, disease stage and primary tumour location. To conclude, a higher pre- and post-diagnostic intake of unprocessed poultry, but not processed meat and unprocessed red meat, was associated with a decreased all-cause mortality risk in individuals with stage I–III CRC. Future studies in independent study populations should confirm these findings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0020-7136 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/468069 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/468069 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5C3BAE0F |
| Database: |
BASE |