| Title: |
Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice. |
| Authors: |
Kahn, Martin; Krone, Lukas B; Blanco-Duque, Cristina; Guillaumin, Mathilde C C; Mann, Edward O; Vyazovskiy, Vladyslav V |
| Source: |
Kahn, Martin; Krone, Lukas B; Blanco-Duque, Cristina; Guillaumin, Mathilde C C; Mann, Edward O; Vyazovskiy, Vladyslav V (2022). Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice. Journal of sleep research, 31(6), e13603. Wiley 10.1111/jsr.13603 |
| Publisher Information: |
Wiley |
| Publication Year: |
2022 |
| Collection: |
BORIS (Bern Open Repository and Information System, University of Bern) |
| Subject Terms: |
610 Medicine & health |
| Description: |
The slow oscillation is a central neuronal dynamic during sleep, and is generated by alternating periods of high and low neuronal activity (ON- and OFF-states). Mounting evidence causally links the slow oscillation to sleep's functions, and it has recently become possible to manipulate the slow oscillation non-invasively and phase-specifically. These developments represent promising clinical avenues, but they also highlight the importance of improving our understanding of how ON/OFF-states affect incoming stimuli and what role they play in neuronal plasticity. Most studies using closed-loop stimulation rely on the electroencephalogram and local field potential signals, which reflect neuronal ON- and OFF-states only indirectly. Here we develop an online detection algorithm based on spiking activity recorded from laminar arrays in mouse motor cortex. We find that online detection of ON- and OFF-states reflects specific phases of spontaneous local field potential slow oscillation. Our neuronal-spiking-based closed-loop procedure offers a novel opportunity for testing the functional role of slow oscillation in sleep-related restorative processes and neural plasticity. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://boris.unibe.ch/170459/ |
| Availability: |
https://boris.unibe.ch/170459/1/Journal_of_Sleep_Research_-_2022_-_Kahn_-_Neuronal_spiking_based_closed_loop_stimulation_during_cortical_ON__and_OFF_states.pdf; https://boris.unibe.ch/170459/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.5C54AA91 |
| Database: |
BASE |