| Title: |
Antioxidant, thrombolytic, cytotoxic and membrane stabilizing activities and fatty acid composition of Acmella Calva (DC.) Flower |
| Authors: |
Rafi, Md Omar Sha; Shristy, Nusrat Tabassum; Mimi, Sauda Sultana; Chhanda, Sadia Afrin; Rahman, Md Hasanur; Rahman, Mohammad Sharifur; Rashid, Mohammad A; Muslim, Tanvir |
| Source: |
Bangladesh Journal of Botany; Vol. 54 No. 3 (2025); 433-439 ; 2079-9926 ; 0253-5416 |
| Publisher Information: |
Bangladesh Botanical Society |
| Publication Year: |
2025 |
| Collection: |
Bangladesh Journals Online (BanglaJOL) |
| Subject Terms: |
Acmella calva; Antioxidant; Thrombolytic Activity; Cytotoxicity; Membrane Stabilizing Activity |
| Time: |
Bangladesh |
| Description: |
In the present study, crude methanolic extract (CRME) of A. calva flower along with its n-hexane (HSF), ethyl acetate (EASF), dichloromethane (DCMSF) and aqueous (AQSF) soluble fractions were subjected to antioxidant, thrombolytic, cytotoxic and membrane stabilizing activities. Fatty acid composition of the n-hexane extract was analysed by gas chromatography-flame ionization detector. None of the extracts showed any cytotoxicity against both carcinoma (HeLa) and normal cell lines (Vero and BHK-21). EASF scavenged the DPPH free radical most actively with IC50 value of 35.05 μg/ml. CRME and HSF showed profound membrane stabilizing activity by protecting human erythrocyte cell against hypotonic solution-induced and heat-induced lysis. CRME showed the highest (46%) clot lysis. Stearic acid (51.11%) and palmitoleic acid (39.38%) were found in the highest amount in both bound and free form of fatty acid, respectively. The observation from this study indicates the possibility of A. calva to be a good source of different bioactive phytochemicals. Bangladesh J. Bot. 54(3): 433-439, 2025 (September) |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://banglajol.info/index.php/BJB/article/view/84427/55118; https://banglajol.info/index.php/BJB/article/view/84427 |
| Availability: |
https://banglajol.info/index.php/BJB/article/view/84427 |
| Rights: |
Copyright (c) 2025 Bangladesh Botanical Society |
| Accession Number: |
edsbas.5C598C8F |
| Database: |
BASE |