| Title: |
Risk Factors for Patient-Important Upper Gastrointestinal Bleeding |
| Authors: |
Deane, Adam M.; Lauzier, François; Adhikari, Neill K. J.; Lamontagne, François; Heels-Ansdell, Diane; Thabane, Lehana; Williamson, David; Kanji, Salmaan; Barletta, Jeffrey F.; Finfer, Simon; Arabi, Yaseen; Ostermann, Marlies; Marshall, John C.; Zytaruk, Nicole L.; Hardie, Miranda; Hammond, Naomi E.; Guyatt, Gordon; White, Kyle C.; Burns, Karen E. A.; Dionne, Joanna C.; Young, Paul J.; Cook, Deborah J. |
| Contributors: |
Canadian Institutes of Health Research; National Health and Medical Research Council of Australia |
| Source: |
American Journal of Respiratory and Critical Care Medicine ; volume 211, issue 9, page 1671-1680 ; ISSN 1073-449X 1535-4970 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Rationale Patient-important gastrointestinal bleeding is an endpoint developed by patients and family members; however, risk factors for this outcome are unknown. Objectives We sought to identify risk factors for patient-important upper gastrointestinal bleeding among invasively ventilated adults. Methods This preplanned regression analysis of an international trial database evaluated baseline and time-varying risk factors in the preceding 3 days for patient-important upper gastrointestinal bleeding, accounting for illness severity and the competing risk of death. Measurements and Main Results Patient-important upper gastrointestinal bleeding occurred in the ICU among 131 of 4,821 (2.7%) patients. Baseline APACHE II score—hazard ratio (HR), 1.24 (95% confidence interval [CI] = 1.12, 1.37) per 5-point increase—and the following were associated with greater risk of patient-important bleeding: inotropes or vasopressors (HR, 2.05 [95% CI = 1.35, 3.12]), severe thrombocytopenia (platelet count, |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1164/rccm.202411-2245oc |
| Availability: |
https://doi.org/10.1164/rccm.202411-2245oc; https://academic.oup.com/ajrccm/article-pdf/211/9/1671/66439829/ajrccm_211_9_1671.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5C676847 |
| Database: |
BASE |