| Title: |
Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis |
| Authors: |
Nachira D.; Lococo F.; Rindi G.; Margaritora S. |
| Contributors: |
Bertoglio, P.; Aprile, V.; Ventura, L.; Cattoni, M.; Nachira, Dania; Lococo, Filippo; Perez, M. R.; Guerrera, F.; Minervini, F.; Querzoli, G.; Bocchialini, G.; Bacchin, D.; Franzi, F.; Rindi, Guido; Bellafiore, S.; Femia, F.; Bogina, G. S.; Solli, P.; Kestenholz, P.; Ruffini, E.; Paci, M.; Margaritora, Stefano; Imperatori, A. S.; Lucchi, M.; Gnetti, L.; Terzi, A. C. |
| Publisher Information: |
Springer |
| Publication Year: |
2022 |
| Collection: |
Università Cattolica del Sacro Cuore: PubliCatt |
| Subject Terms: |
Adenocarcinoma subtypes; Lung adenocarcinoma; Lung cancer; TNM staging; Settore MED/21 - CHIRURGIA TORACICA |
| Description: |
Objective: The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas. Methods: We retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph-node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns. Results: Among 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p = 0.020), but the latter had similar OS compared to T2a (p = 0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p = 0.034), and it was similar to T2a (p = 0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p = 0.024; HR 1.285 95% CI 1.033–1.599) and DFS (p = 0.003; HR 1.196, 95% CI 1.054–1.344, respectively). These results were confirmed after the propensity score matching analysis. Conclusions: pT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35988096; info:eu-repo/semantics/altIdentifier/wos/WOS:000842421800001; volume:200; issue:5; firstpage:649; lastpage:660; numberofpages:12; issueyear:2022; journal:LUNG; https://hdl.handle.net/10807/246337 |
| DOI: |
10.1007/s00408-022-00561-y |
| Availability: |
https://hdl.handle.net/10807/246337; https://doi.org/10.1007/s00408-022-00561-y |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5C7EEA4F |
| Database: |
BASE |