| Title: |
Serum KL-6 could represent a reliable indicator of unfavourable outcome in patients with COVID-19 pneumonia |
| Authors: |
Scotto R.; Pinchera B.; Perna F.; Atripaldi L.; Giaccone A.; Sequino D.; Zappulo E.; Sardanelli A.; Moriello N. S.; Stanziola A.; Bocchino M.; Gentile I.; Sanduzzi Zamparelli A. |
| Contributors: |
Scotto, R.; Pinchera, B.; Perna, F.; Atripaldi, L.; Giaccone, A.; Sequino, D.; Zappulo, E.; Sardanelli, A.; Moriello, N. S.; Stanziola, A.; Bocchino, M.; Gentile, I.; Sanduzzi Zamparelli, A. |
| Publication Year: |
2021 |
| Collection: |
IRIS Università degli Studi di Napoli Federico II |
| Subject Terms: |
COVID-19; KL-6; Mortality; Pneumonia; SARS-CoV-2; Biomarker; Female; Human; Male; Middle Aged; Mucin-1 |
| Description: |
KL-6 is a sialoglycoprotein antigen which proved elevated in the serum of patients with different interstitial lung diseases, especially in those with a poorer outcome. Given that interstitial pneumonia is the most common presentation of SARS-CoV2 infection, we evaluated the prognostic role of KL-6 in patients with COVID-19 pneumonia. Patients with COVID-19 pneumonia were prospectively enrolled. Blood samples were collected at the time of enrolment (TOE) and on day 7 (T1). Serum KL-6 concentrations were measured by chemiluminescence enzyme immunoassay using a KL-6 antibody kit (LUMIPULSE G1200, Fujirebio) and the cut-off value was set at > 1000 U/mL. Fifteen out of 34 enrolled patients (44.1%) died. Patients with unfavourable outcome showed significantly lower P/F ratio and higher IL-6 values and plasmatic concentrations of KL-6 at TOE compared with those who survived (median KL-6: 1188 U/mL vs. 260 U/mL, p < 0.001). KL-6 > 1000 U/mL resulted independently associated with death (aOR: 11.29, p < 0.05) with a positive predictive value of 83.3%. Our results suggest that KL-6 is a reliable indicator of pulmonary function and unfavourable outcome in patients with COVID-19 pneumonia. A KL-6 value > 1000 U/mL resulted independently associated with death and showed good accuracy in predicting a poorer outcome. KL-6 may thus represent a quick, inexpensive, and sensitive parameter to stratify the risk of severe respiratory failure and death. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000623593800001; volume:18; issue:4; firstpage:1; lastpage:11; numberofpages:11; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; https://hdl.handle.net/11588/847190 |
| DOI: |
10.3390/ijerph18042078 |
| Availability: |
https://hdl.handle.net/11588/847190; https://doi.org/10.3390/ijerph18042078 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.5C8CA3FA |
| Database: |
BASE |