| Title: |
Roles of Ceramides in Non-Alcoholic Fatty Liver Disease |
| Authors: |
Hajduch, Eric; Lachkar, Floriane; Ferré, Pascal; Foufelle, Fabienne |
| Contributors: |
Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); ANR-18-CE17-0022,SONIC,Sphingolipides hépatiques dans la NAFLD: de la biosynthèse hépatique aux conséquences métaboliques(2018) |
| Source: |
ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.sorbonne-universite.fr/hal-03163597 ; Journal of Clinical Medicine, 2021, 10 (4), pp.792. ⟨10.3390/jcm10040792⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2021 |
| Subject Terms: |
ceramide; liver; NAFLD; NASH; sphingolipids; steatosis; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Description: |
International audience ; Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/jcm10040792 |
| Availability: |
https://hal.sorbonne-universite.fr/hal-03163597; https://hal.sorbonne-universite.fr/hal-03163597v1/document; https://hal.sorbonne-universite.fr/hal-03163597v1/file/jcm-10-00792-v2.pdf; https://doi.org/10.3390/jcm10040792 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5C9A0923 |
| Database: |
BASE |