| Title: |
A randomised controlled trial to investigate the clinical effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for depressed non-responders to Increasing Access to Psychological Therapies (IAPT) high-intensity therapies: study protocol |
| Authors: |
Barnhofer, T; Dunn, BD; Strauss, C; Ruths, F; Barrett, B; Ryan, M; Ladwa, A; Stafford, F; Fichera, R; Baber, H; McGuinness, A; Metcalfe, I; Harding, D; Walker, S; Ganguli, P; Rhodes, S; Young, A; Warren, F |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2026 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background: Non-remission after psychological therapy for major depressive disorder is common, yet there are no established further-line treatments. In the UK National Health Service (NHS) Talking Therapies programme, about 50% of patients with depression who come to the end of the stepped care pathway do not show remission of symptoms. We aimed to investigate whether mindfulness-based cognitive therapy (MBCT) can improve clinical outcomes and whether the additional financial cost is worthwhile. Methods: We conducted a parallel, randomised, controlled, superiority trial in three sites in the UK (Devon, London, and Sussex). Patients with current major depressive disorder whose symptoms had not reached remission (assessed as Patient Health Questionnaire-9 [PHQ-9] score ≥10) after an adequate dose of NHS Talking Therapies high-intensity therapy (≥12 sessions) were recruited from 20 NHS Talking Therapies services. Participants were allocated through remote random assignment (1:1) to MBCT plus treatment as usual or treatment as usual alone at the UK Clinical Research Collaboration-registered Exeter Clinical Trials Unit with minimisation on depression severity (PHQ-9 score |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s13063-022-06882-w |
| Availability: |
https://doi.org/10.1186/s13063-022-06882-w; https://ora.ox.ac.uk/objects/uuid:271b2290-bae3-4e1c-a4a2-b85ee6abaaf4 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.5CACD197 |
| Database: |
BASE |