| Description: |
Introduction. The study of pathogenetic factors of obesity is an urgent task of modern medicine. The formation of obesity is characterized by changes in the activity of individual mechanisms of innate immunity. At the same time, the values of laboratory indicators that characterize them are often within the current boundaries of the reference values of laboratory indicators of the immunity of a healthy person. This complicates the pathogenetic assessment of the mechanisms of nonspecific immunological reactivity in obesity and determines the need for further study of the characteristics of nonspecific immune defense factors in this pathology.Aim. To identify the features of changes in cellular and humoral factors of nonspecific immunological reactivity in obesity.Materials and methods. A single-center cross-sectional, one-time controlled study was conducted with the participation of 118 people, of which 87 people were obese patients (BMI 37.2 [34.1; 42.05] kg/m2), 31 people had normal body weight (BMI 21.9 [ 20.2; 23.5] kg/m2) and were included in the control group. All patients underwent a study of lipid profile (total cholesterol, high-density lipoproteins, low-density lipoproteins, very low-density lipoproteins, triglycerides), carbohydrate metabolism (glucose, insulin, glycated hemoglobin), C-reactive protein, indicators of cellular and humoral factors of nonspecific immunity (leukogram, cytokine profile, C3-C4 complement components).Results. An increase in the total number of leukocytes was revealed, due to neutrophil granulocytes against the background of the development of a disproportion between the percentage and absolute value of the number of lymphocytes and monocytes, the concentration of C3 and C4 complement components, C-reactive protein, as well as an increase in the level of IL-6, which confirms the presence of low-grade chronic inflammation in obese patients. Statistically significant correlations of immunological parameters with anthropometric data, indicators of carbohydrate and lipid ... |
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https://www.med-sovet.pro/jour/article/view/8634/7582; DeJesus RS, Croghan IT, Jacobson DJ, Fan C, St Sauver J. Incidence of Obesity at 1 and 3 Years Among Community Dwelling Adults: A Population-Based Study. J Prim Care Community Health. 2022;13:21501319211068632. https://doi.org/10.1177/21501319211068632.; Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance. Science. 1993;259(5091):87–91. https://doi.org/10.1126/science.7678183.; Hotamisligil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 2017;47(3):406–420. https://doi.org/10.1016/j.immuni.2017.08.009.; Cottam MA, Itani HA, Beasley AA 4th, Hasty AH. Links between Immunologic Memory and Metabolic Cycling. J Immunol. 2018;200(11):3681–3689. https://doi.org/10.4049/jimmunol.1701713.; Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C, Beguinot F. Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front Physiol. 2020;10:1607. https://doi.org/10.3389/fphys.2019.01607.; Schleh MW, Caslin HL, Garcia JN, Mashayekhi M, Srivastava G, Bradley AB, Hasty AH. Metaflammation in obesity and its therapeutic targeting. Sci Transl Med. 2023;15(723):eadf9382. https://doi.org/10.1126/scitranslmed.adf9382.; Taylor EB. The complex role of adipokines in obesity, inflammation, and autoimmunity. Clin Sci (Lond). 2021;135(6):731–752. https://doi.org/10.1042/CS20200895.; Скворцова ОВ, Мигачева НБ, Михайлова ЕГ. Иммунометаболические аспекты хронического неспецифического воспаления на фоне ожирения. Медицинский совет. 2023;17(12):75–82. https://doi.org/10.21518/ms2023-187.; Meister BM, Hong SG, Shin J, Rath M, Sayoc J, Park JY. Healthy versus unhealthy adipose tissue expansion: the role of exercise. J Obes Metab Syndr. 2022;31(1):37–50. https://doi.org/10.7570/jomes21096.; Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851–863. https://doi.org/10.5114/aoms.2016.58928.; Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822–1832. https://doi.org/10.1038/s41591-019-0675-0.; Luna-Vital D, Luzardo-Ocampo I, Cuellar-Nuñez ML, Loarca-Piña G, Gonzalez de Mejia E. Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways. J Nutr Biochem. 2020;79:108343. https://doi.org/10.1016/j.jnutbio.2020.108343.; Michailidou Z, Gomez-Salazar M, Alexaki VI. Innate immune cells in the adipose tissue in health and metabolic disease. J Innate Immun. 2022;14(1):4–30. https://doi.org/10.1159/000515117.; Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375–C391. https://doi.org/10.1152/ajpcell.00379.2020.; Uribe-Querol E, Rosales C. Neutrophils Actively Contribute to Obesity-Associated Inflammation and Pathological Complications. Cells. 2022;11(12):1883. https://doi.org/10.3390/cells11121883.; Acciarino A, Diwakarla S, Handreck J, Bergola C, Sahakian L, McQuade RM. The role of the gastrointestinal barrier in obesity-associated systemic inflammation. Obes Rev. 2024;25(3):e13673. https://doi.org/10.1111/obr.13673.; Choi J, Joseph L, Pilote L. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obes Rev. 2013;14(3):232–244. https://doi.org/10.1111/obr.12003.; Oussaada SM, Kilicarslan M, de Weijer BA, Gilijamse PW, Şekercan A, Virtue S et al. Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Res Clin Pract. 2024;211:111663. https://doi.org/10.1016/j.diabres.2024.111663.; Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond). 2006;30(9):1347–1355. https://doi.org/10.1038/sj.ijo.0803259.; Breslin WL, Johnston CA, Strohacker K, Carpenter KC, Davidson TR, Moreno JP et al. Obese Mexican American children have elevated MCP-1, TNF-α, monocyte concentration, and dyslipidemia. Pediatrics. 2012;129(5):e1180–1186. https://doi.org/10.1542/peds.2011-2477.; Takiishi T, Fenero CIM, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017;5(4):e1373208. https://doi.org/10.1080/21688370.2017.1373208.; Dommel S, Bluher M. Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State? Int J Mol Sci. 2021;22(3):1500. https://doi.org/10.3390/ijms22031500.; Santamarina AB, Calder PC, Estadella D, Pisani LP. Anthocyanins ameliorate obesity-associated metainflammation: Preclinical and clinical evidence. Nutr Res. 2023;114:50–70. https://doi.org/10.1016/j.nutres.2023.04.004.; Varra FN, Varras M, Varra VK, Theodosis-Nobelos P. Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation-mediating treatment options (Review). Mol Med Rep. 2024;29(6):95. https://doi.org/10.3892/mmr.2024.13219. |
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