| Title: |
Massive lactic acidosis and ketoacidosis with glucagon deficiency in a chronic alcoholic patient. |
| Authors: |
Boudou, Philippe; Djibré, Michel; Ibrahim, Fidaa; Fellahi, Soraya; Gilon, Patrick; Andreelli, Fabrizio; Ferré, Pascal; Boissan, Mathieu |
| Contributors: |
UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition |
| Source: |
Diabetes & metabolism, Vol. 47, no. 3, p. 101170 [1-3] (2021) |
| Publisher Information: |
Masson |
| Publication Year: |
2021 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Description: |
A non-diabetic chronic alcoholic and undernourished male patient [body mass index (BMI): 16.6 kg/m2] was admitted to our hospital emergency department. He had fasted for the previous 3 days. His blood lactate and ketone body concentrations were massively elevated (18 mmol/L and 14 mmol/L, respectively). Ethanolaemia was negative. Massive metabolic acidosis was noted with a pH of 7.04. Renal function remained normal, but there was mild hepatocellular deficiency and no acute pancreatitis. The patient was hypoglycaemic at admission with a blood glucose level of 3.0 mmol/L, and low concentrations of insulin, C-peptide and insulin-like growth factor (IGF)-1, as well as very low glucagon concentrations (5.2 ng/L; normal range: 8–74 ng/L) despite the prevailing glycaemia. In contrast, cortisol, sex hormone-binding globulin (SHBG) and growth hormone (GH) concentrations were elevated. [.] |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:230664; http://hdl.handle.net/2078.1/230664; info:pmid/32531474 |
| DOI: |
10.1016/j.diabet.2020.05.011 |
| Availability: |
http://hdl.handle.net/2078.1/230664; https://doi.org/10.1016/j.diabet.2020.05.011 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.5D260FE3 |
| Database: |
BASE |