| Title: |
Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19. |
| Authors: |
Scutelnic, Adrian; van de Munckhof, Anita; Miraclin, Angel T; Aaron, Sanjith; Hameed, Sajid; Wasay, Mohammad; Grosu, Oxana; Krzywicka, Katarzyna; Sánchez van Kammen, Mayte; Lindgren, Erik; Moreira, Tiago; Acampora, Roberto; Negro, Alberto; Karapanayiotides, Theodoros; Yaghi, Shadi; Revert, Anna; Cuadrado Godia, Elisa; Garcia-Madrona, Sebastian; La Spina, Paolino; Grillo, Francesco; Giammello, Fabrizio; Nguyen, Thanh N; Abdalkader, Mohamad; Buture, Alina; Sofia Cotelli, Maria; Raposo, Nicolas; Tsivgoulis, Georgios; Candelaresi, Paolo; Ciacciarelli, Antonio; Mbroh, Joshua; Batenkova, Tatiana; Scoppettuolo, Pasquale; Zedde, Marialuisa; Pascarella, Rosario; Antonenko, Kateryna; Kristoffersen, Espen S; Kremer Hovinga, Johanna A; Jood, Katarina; Aguiar de Sousa, Diana; Poli, Sven; Tatlisumak, Turgut; Putaala, Jukka; Coutinho, Jonathan M; Ferro, José M; Arnold, Marcel; Heldner, Mirjam R |
| Contributors: |
UCL - SSS/IONS - Institute of NeuroScience; UCL - (SLuc) Service de neurologie |
| Source: |
European stroke journal, Vol. 9, no.3, p. 676-686 (2024) |
| Publisher Information: |
SAGE Publications Ltd |
| Publication Year: |
2024 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Subject Terms: |
Humans; COVID-19; Female; Male; Middle Aged; Intracranial Thrombosis; Venous Thrombosis; Registries; Adult; Aged; Length of Stay; SARS-CoV-2; Hospital Mortality; Cerebral venous thrombosis; stroke |
| Description: |
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. RESULTS: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]). CONCLUSION: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:300517; http://hdl.handle.net/2078.1/300517; info:pmid/38572798 |
| DOI: |
10.1177/23969873241241885 |
| Availability: |
http://hdl.handle.net/2078.1/300517; https://doi.org/10.1177/23969873241241885 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.5D4DFB2 |
| Database: |
BASE |