| Title: |
Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity |
| Authors: |
Giovenzana A.; Bezzecchi E.; Bichisecchi A.; Cardellini S.; Ragogna F.; Pedica F.; Invernizzi F.; Di Filippo L.; Tomajer V.; Aleotti F.; Scotti G. M.; Socci C.; Cesana G.; Olmi S.; Morelli M. J.; Falconi M.; Giustina A.; Bonini C.; Piemonti L.; Ruggiero E.; Petrelli A. |
| Contributors: |
Giovenzana, A; Bezzecchi, E; Bichisecchi, A; Cardellini, S; Ragogna, F; Pedica, F; Invernizzi, F; Di Filippo, L; Tomajer, V; Aleotti, F; Scotti, G; Socci, C; Cesana, G; Olmi, S; Morelli, M; Falconi, M; Giustina, A; Bonini, C; Piemonti, L; Ruggiero, E; Petrelli, A |
| Publisher Information: |
Cell Press Elsevier Inc; US |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Health science; Obesity medicine |
| Description: |
Obesity is characterized by the accumulation of T cells in insulin-sensitive tissues, including the visceral adipose tissue (VAT), that can interfere with the insulin signaling pathway eventually leading to insulin resistance (IR) and type 2 diabetes. Here, we found that PD-1+CD4 conventional T (Tconv) cells, endowed with a transcriptomic and functional profile of partially dysfunctional cells, are diminished in VAT of obese patients with dysglycemia (OB-Dys), without a concomitant increase in apoptosis. These cells showed enhanced capacity to recirculate into the bloodstream and had a non-restricted TCRβ repertoire divergent from that of normoglycemic obese and lean individuals. PD-1+CD4 Tconv were reduced in the circulation of OB-Dys, exhibited an altered migration potential, and were detected in the liver of patients with non-alcoholic steatohepatitis. The findings suggest a potential role for partially dysfunctional PD-1+CD4 Tconv cells as inter-organ mediators of IR in obese patients with dysglycemic. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38380252; info:eu-repo/semantics/altIdentifier/wos/WOS:001188885000001; volume:27; issue:3; journal:ISCIENCE; https://hdl.handle.net/10281/504763 |
| DOI: |
10.1016/j.isci.2024.109032 |
| Availability: |
https://hdl.handle.net/10281/504763; https://doi.org/10.1016/j.isci.2024.109032 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5D6974A2 |
| Database: |
BASE |