| Title: |
Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy |
| Authors: |
Rasing,Ingeborg; Vlegels, Naomi; Schipper,Manon R.; Voigt,Sabine; Koemans,Emma A.; Kaushik,Kanishk; van Dort,Rosemarie; van Harten,Thijs W.; De Luca, Alberto; van Etten,Ellis S.; van Zwet,Erik W.; van Buchem,Mark A.; Middelkoop,Huub A.M.; Biessels, Geert Jan; Terwindt,Gisela M.; van Osch,Matthias J.P.; van Walderveen,Marianne A.A.; Wermer,Marieke J.H.; Projectafdeling VCI; Beeldverwerking ISI; Brain; Cancer; Neurologen; Circulatory Health |
| Publication Year: |
2024 |
| Subject Terms: |
Cerebral amyloid angiopathy; cognitive impairment; diffusion magnetic resonance imaging; Dutch-type hereditary cerebral amyloid angiopathy; MRI CAA-small vessel disease burden; Neurology; Clinical Neurology; Cardiology and Cardiovascular Medicine |
| Description: |
Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/symptomatic; mean age 39/58 y). PSMD-levels increased with disease severity and were higher in symptomatic D-CAA mutation-carriers (median [range] 4.90 [2.77–9.50]mm2/s × 10−4) compared with presymptomatic mutation-carriers (2.62 [1.96–3.43]mm2/s × 10−4) p = |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0271-678X |
| Relation: |
https://dspace.library.uu.nl/handle/1874/458015 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/458015 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5D6C0E33 |
| Database: |
BASE |