| Title: |
Pancreatic insufficiency as a complication of type 1 diabetes causing enteric hyperoxaluria in a transplant kidney |
| Authors: |
Chambers, Joshua; Appleton, Alice; Dudley, Christopher |
| Source: |
BMJ Case Reports ; volume 15, issue 7, page e248162 ; ISSN 1757-790X |
| Publisher Information: |
BMJ |
| Publication Year: |
2022 |
| Description: |
A kidney transplant recipient with a medical history of type 1 diabetes mellitus (T1DM) presents to the clinic with an acute kidney injury (AKI) and diarrhoea. Kidney biopsy found deposition of focal oxalate crystals, and further investigation revealed a raised 24-hour urinary oxalate and reduced faecal elastase. Therefore, we present a case of acute oxalate nephropathy (AON) secondary to enteric hyperoxaluria as a result of pancreatic insufficiency caused by T1DM. T1DM is a common cause of end-stage renal failure and exocrine pancreatic insufficiency. Therefore, AON secondary to enteric hyperoxaluria should be considered in patients with a transplant AKI. Earlier testing of 24-hour urinary oxalate and faecal elastase could generate diagnosis before biopsy results and allow commencement of pancreatic replacement therapy earlier to avoid permanent loss of kidney function. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/bcr-2021-248162 |
| Availability: |
https://doi.org/10.1136/bcr-2021-248162; https://syndication.highwire.org/content/doi/10.1136/bcr-2021-248162 |
| Accession Number: |
edsbas.5D9DDF5D |
| Database: |
BASE |