| Title: |
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies |
| Authors: |
Watts, EL; Perez-Cornago, A; Appleby, PN; Albanes, D; Ardanaz, E; Black, A; Bueno-de-Mesquita, HB; Chan, JM; Chen, C; Chubb, SAP; Cook, MB; Deschasaux, M; Donovan, JL; English, DR; Flicker, L; Freedman, ND; Galan, P; Giles, GG; Giovannucci, EL; Gunter, MJ; Habel, LA; Häggström, C; Haiman, C; Hamdy, FC; Hercberg, S; Holly, JM; Huang, J; Huang, WY; Johansson, M; Kaaks, R; Kubo, T; Lane, JA; Layne, TM; Le Marchand, L; Martin, RM; Metter, EJ; Mikami, K; Milne, RL; Morris, HA; Mucci, LA; Neal, DE; Neuhouser, ML; Oliver, SE; Overvad, K; Ozasa, K; Pala, V; Pernar, CH; Pollak, M; Rowlands, MA; Schaefer, CA; Schenk, JM; Stattin, P; Tamakoshi, A; Thysell, E; Touvier, M; Trichopoulou, A; Tsilidis, KK; Van Den Eeden, SK; Weinstein, SJ; Wilkens, L; Yeap, BB; Key, TJ; Allen, NE; Travis, RC |
| Publisher Information: |
WILEY |
| Publication Year: |
2019 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0020-7136 |
| Relation: |
https://hdl.handle.net/11343/251125 |
| Availability: |
https://hdl.handle.net/11343/251125 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.5DA21366 |
| Database: |
BASE |