| Title: |
Urine and plasma metanephrine concentrations in cats with chronic kidney disease: characterization and correlation with biomarkers of renal function |
| Authors: |
Marques, Patricia L; Domingues, Tiago D; Filipe, Ana I; Ferreira, Rui L; Junius, Greet; Patteet, Lisbeth; Van den Steen, Evi; Mateus, Luísa; Galac, Sara; Leal, Rodolfo O; Interne geneeskunde GD; OnGo; CS_Cancer |
| Publication Year: |
2026 |
| Subject Terms: |
adrenal function; adrenal medulla; catecholamines; sympathetic nervous system; General Veterinary |
| Description: |
BACKGROUND: The role of the autonomic nervous system in the pathophysiology of chronic kidney disease (CKD) in cats is currently unknown. HYPOTHESIS/OBJECTIVES: To describe urine and plasma metanephrines concentration in cats with CKD and their correlation with biomarkers of kidney function. ANIMALS: Fifty-nine cats were recruited and divided into 3 groups: cats with CKD (n = 28), healthy cats (HC) (n = 21), and cats with nonadrenal, non-kidney-related chronic illness (n = 10). METHODS: A cross-sectional study was performed in cats recruited from a veterinary teaching hospital. Metanephrine and normetanephrine concentrations were measured in urine (U-MN/NMN) and plasma (P-MN/NMN) by liquid chromatography tandem mass spectrometry. Data were correlated with biomarkers of kidney function measured in the same time-point sample. RESULTS: The CKD group had significantly higher P-NMN (median, 14.20; min-max, 5.65-34.09 nmol/L) than the HC group (7.03; 5.19-13.03 nmol/L). P-MN concentrations correlated with the urinary protein-creatinine ratio (UPCR) (r = 0.528, P = .017). P-NMN correlated with symmetric dimethylarginine (SDMA) (r = 0.604, P = .006), serum creatinine (r = 0.488, P = .029) and UPCR (r = 0.445, P = .049). U-MN:urine creatinine concentration (UCreat) ratio correlated with UPCR (r = 0.683, P < .001) and urine specific gravity (r = -0.397), P < .001). U-NMN:UCreat ratio correlated with SDMA (r = 0.558, P = .007), serum phosphate (r = 0.561, P = .005) and UPCR (r = 0.494, P = .017). CONCLUSION AND CLINICAL IMPORTANCE: There is evidence of sympathetic nervous system dysfunction in cats with CKD. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0891-6640 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/480935 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/480935 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5DAFBB60 |
| Database: |
BASE |