Disruptive chemicals, senescence and immortality
| Title: | Disruptive chemicals, senescence and immortality |
|---|---|
| Authors: | Carnero A; Blanco-Aparicio C; Kondoh H; Lleonart ME; Martinez-Leal JF; Mondello C; Scovassi AIvana; Bisson WH; Amedei A; Roy R; Woodrick J; Colacci A; Vaccari M; Raju J; Al-Mulla F; Al-Temaimi R; Salem HK; Memeo L; Forte S; Singh N; Hamid RA; Ryan EP; Brown DG; Wise JP; Wise SS; Yasaei H. |
| Source: | Carcinogenesis (N.Y., Online) 36 (2015): S19–S37. doi:10.1093/carcin/bgv029 ; info:cnr-pdr/source/autori:Carnero A, Blanco-Aparicio C, Kondoh H, Lleonart ME, Martinez-Leal JF, Mondello C, Scovassi AIvana, Bisson WH, Amedei A, Roy R, Woodrick J, Colacci A, Vaccari M, Raju J, Al-Mulla F, Al-Temaimi R, Salem HK, Memeo L, Forte S, Singh N, Hamid RA, Ryan EP, Brown DG, Wise JP, Wise SS, Yasaei H./titolo:Disruptive chemicals, senescence and immortality/doi:10.1093carcinbgv029/rivista:Carcinogenesis (N.Y., Online)/anno:2015/pagina_da:S19/pagina_a:S37/intervallo_pagine:S19–S37/volume:36 |
| Publisher Information: | Oxford University Press, Oxford , Regno Unito |
| Publication Year: | 2015 |
| Collection: | PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Subject Terms: | environmental chemical; cancer; senenscence; cellular immortality |
| Description: | Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection is the driving force behind tumorigenesis and possesses three basic requirements: (i) effective competitive proliferation of the variant clone when compared with its neighboring cells, (ii) acquisition of an indefinite capacity for self-renewal, and (iii) establishment of sufficiently high levels of genetic and epigenetic variability to permit the emergence of rare variants. However, several questions regarding the process of clonal evolution remain. Which cellular processes initiate carcinogenesis in the first place? To what extent are environmental carcinogens responsible for the initiation of clonal evolution? What are the roles of genotoxic and non-genotoxic carcinogens in carcinogenesis? |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:cnr-pdr/author/matricola:19184/SCOVASSI/ANNA; info:cnr-pdr/author/matricola:39138/MONDELLO/CHIARA; http://www.cnr.it/prodotto/i/333248; https://publications.cnr.it/doc/333248; https://dx.doi.org/10.1093/carcin/bgv029; info:doi:10.1093/carcin/bgv029 |
| DOI: | 10.1093/carcin/bgv029 |
| Availability: | http://www.cnr.it/prodotto/i/333248; https://publications.cnr.it/doc/333248; https://doi.org/10.1093/carcin/bgv029; http://www.scopus.com/inward/record.url?eid=2-s2.0-84935091493&partnerID=q2rCbXpz |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| Accession Number: | edsbas.5DBCEC7B |
| Database: | BASE |