Global, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
| Title: | Global, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 |
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| Authors: | Cousin E; Nascimento BR; Whisnant JL; Zimsen SRM; Harris AA; Machado IE; Martins-Melo FR; Demacq C; Perel P; Geissbuhler Y; Abbasi M; Abdel-Hameed R; Abdul Aziz JM; Abedi A; Abramov D; Abu-Gharbieh E; Adegboye OA; Afzal MS; Afzal S; Ahmad S; Ahmed A; Akinosoglou K; Al Awaidy S; Ali SS; Almazan JU; Alshahrani NZ; Alvis-Zakzuk NJ; Anvari S; Arab JP; Arabloo J; Aravkin A AY; Areda D; Aregawi BB; Aremu A; Athari SS; Babu GR; Baltatu OC; Banach M; Barqawi HJ; Bastan M-M; Behjati J; Belayneh M; Beloukas A; Bhaskar S; Bhattacharjee P; Boppana SH; Briko NI; Bustanji Y; Carneiro M; Carvalho F; Cenderadewi M; Chattu VK; Chaudhary AA; Ching PR; Cosma C; Dadras O; Dai X; Darcho SD; Devegowda D; Diaz D; Dourado PMM; Durojaiye OC; E'mar AR; Ed-Dra A; Efendi F; Ekundayo TC; Elhadi M; Elshaer M; Fagbamigbe AF; Foroutan M; Franklin RC; Fux B; Gautam RK; Gebregergis MW; Ghimire S; Gupta H; Hasaballah AI; Hatam-Nahavandi K; Hay SI; He J; Ilesanmi OS; Ilic IM; Ilic MD; Jakovljevic M; Jalili M; Joseph N; Kanmodi KK; Khatab K; KM S; Kulimbet M; Kyto V; Le MHN; Le TTT; Lee SW; Lim SS; Manla Y; Martinez-Guerra BA; Mekene Meto T; Meles HN; Mestrovic T; Mokdad AH; Molina I; Moni MA; Mubarak R; Mubarik S; Murray CJL; Natto ZS; Nguyen VT; Niyonsenga JMV; Nugen F; Odetokun IA; Okonji OC; Ordak M; Orish VN; Ortiz-Prado E; Ouyahia A; Pando-Robles V; Passera R; Pawar S; Peprah P; Pereira A; Perez Chacon G; Pineiro DJ; Porntaveetus T; Rahim F; Rahman M; Rahmani S; Ramadan MM; Ramasamy SK; Rasouli-Saravani A; Rocha HAL; Rodriguez JAB; Roever L; Roy P; Sabet CJ; Saeed U; Safari M; Saheb Sharif-Askari F; Saheb Sharif-Askari N; Salam N; Salami AA; Sarkar T; Sarmiento-Suarez R; Shahid S; Shamim MA; Shannawaz M; Sherchan SP; Shittu A; Shorofi SA; Siddig EE; Singh P; Singh S; Swain CK; Szarpak L; Tiwari K; Tovani-Palone MR; Wickramasinghe ND; Wu S; Yaghoubi S; Yahya G; Yon DK; Zamora N; Zastrozhin M; Zeariya MGM; Zeb J; Zhang H; Zheng J; Mosser JF; Ribeiro ALP |
| Source: | The Lancet Infectious Diseases, March 2026 |
| Publisher Information: | Elsevier Ltd |
| Publication Year: | 2026 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © 2025 Elsevier LtdBackground: Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi, primarily transmitted by infected bugs, but also through contaminated food, transfusions, congenital transmission, and organ transplantation. Chagas disease has acute and chronic phases; the chronic phase can occur decades after infection, leading to complications such as heart failure, arrhythmias, and megaviscera. Accurate mortality and morbidity estimates are hindered by under-reporting and misclassification. Comprehensive and updated estimates are needed to improve global assessments of Chagas disease burden. We aim to provide a comprehensive description of global and regional burden of Chagas disease and its trends from 1990 to 2023. Methods: In this systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, we produced estimates of Chagas disease deaths, years of life lost (YLLs), prevalence, incidence, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 204 countries and territories from 1990 to 2023 by age and sex. The GBD 2023 estimates supersede previous estimates for all years. For mortality estimates, we fit a cause of death ensemble model to vital registration data. For non-fatal estimates in endemic locations, we did a systematic review of seroprevalence data, defining a confirmed case as a confirmed diagnosis of T cruzi infection by two different positive tests (or a single ELISA or immunochromatographic test). After adjustment for the population at risk, we used a Bayesian compartmental model (DisMod-MR) to produce estimates. For non-endemic locations, we estimated prevalence on the basis of migration patterns and estimated prevalence from endemic countries. Prevalence of acute and chronic sequelae and corresponding disability weights were used to calculate YLDs. Findings: We estimated 10·5 million (95% uncertainty interval 9·4–11·7) Chagas disease prevalent cases in 2023 globally, a 16·1% (12·6–19·2) ... |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/310943 |
| Availability: | https://eprints.ncl.ac.uk/310943 |
| Accession Number: | edsbas.5DF2BB41 |
| Database: | BASE |