External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: results from the Registro Informatizado Enfermedad TromboEmbὀlica Registry
| Title: | External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: results from the Registro Informatizado Enfermedad TromboEmbὀlica Registry |
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| Authors: | Hoberstorfer T.; Nopp S.; Steiner D.; Hernandez-Blasco L.; Jou I.; Lopez-Nunez J. J.; Fidalgo A.; Lopez-Miguel P.; Monreal M.; Ay C.; Prandoni P.; Brenner B.; Farge-Bancel D.; Barba R.; Verhamme P.; Yoo H. H. B.; Maly R.; Bertoletti L.; Schellong S.; Tzoran I.; Di Micco P.; Reis A.; Bosevski M.; Mazzolai L.; Joseph A.; Caprini; Bui H. M.; Adarraga M. D.; Aibar J.; Alberich-Conesa A.; Alda-Lozano A.; Alfonso J.; Amado C.; Angelina-Garcia M.; Arcelus J. I.; Ballaz A.; Barbagelata C.; Barron M.; Barron-Andres B.; Bencosme-de Mendez E. I.; Blanco-Molina A.; Bonavila C. S.; Caballero J. C.; Cantarella R. F.; Chasco L.; Claver G.; Crecente P.; Criado J.; De Ancos-Aracil C.; De Juana-Izquierdo C.; Del Toro J.; Demelo-Rodriguez P.; Diaz-Brasero A. M.; Diaz-Pedroche M. C.; Diaz-Peromingo J. A.; Dubois-Silva A.; Duran D.; Escribano J. C.; Farfan-Sedano A. I.; Fernandez-Bermejo L. A.; Fernandez-Capitan C.; Fernandez-Reyes J. L.; Fidalgo M. A.; Francisco I.; Gabara C.; Galeano-Valle F.; Garcia-Bragado F.; Garcia-Ortega A.; Gavin-Sebastian O.; Gil-Diaz A.; Gomez-Cepeda C.; Gomez-Cuervo C.; Gonzalez-Martinez J. G.; Gonzalez-Munera A.; Gonzalez-Olmedo J.; Gorostidi-Perez J.; Grau E.; Guirado L.; Gutierrez-Guisado J.; Heredia-Mena C.; Hernandez-Vidal M. J.; Jara-Palomares L.; Jimenez D.; Joya M. D.; Lainez-Justo S.; Lecumberri R.; Llamas P.; Lopez-Brull H.; Lopez-Jimenez L.; Lopez-Ruiz A.; Lopez-Saez J. B.; Lorenzo A.; Madronal-Cerezo E.; Maestre A.; Marchena P. J.; Marcos M.; Martin-del Pozo M.; Mas-Maresma L.; Mercado M. I.; Monzon L.; Nieto J. A.; Nunez-Fernandez M. J.; Olivares M. C.; Ordieres-Ortega L.; Ortiz M.; Otalora S.; Otero R.; Pagan J.; Parra-Caballero P.; Payro-Bisart N.; Pedrajas J. M.; Perez-Ductor C.; Perez-Pinar M.; Peris M. L.; Pesce M. L.; Porras J. A.; Prieto-Ganan L. M.; Puchades R.; Puche G.; Raposo S.; Rivas A.; Rivera-Civico F.; Rodriguez-Cobo A.; Ruiz-Gimenez N.; Salgueiro G.; Sanchez-Serrano M.; Sancho T.; Sendin V.; Sole A.; Soler S.; Suarez-Fernandez S.; Teres-Pueyo L.; Tolosa C.; Torres M. I.; Trujillo-Santos J.; Uresandi F.; Valle R.; Varona J. F.; Vazquez E.; Vega-Romero E.; Vela-Moreno J. R.; Vela-Valle L.; Vidal G.; Villares P.; Pabinger I.; Van Thillo Q.; Vanassche T.; Jimenez-Echandia C. A.; Montenegro A. C.; Roa J.; Hirmerova J.; Accassat S.; Bura-Riviere A.; Catella J.; Chopard R.; Espitia O.; Leclercq B.; Mahe I.; Moustafa F.; Plaisance L.; Poenou G.; Quere I.; Sarlon-Bartoli G.; Suchon P.; Versini E.; Jenab Y.; Khodayari A.; Sadeghipour P.; Yadangi S.; Dally N.; Kenet G.; Barillari G.; Basaglia M.; Bazza A.; Bilora F.; Bissacco D.; Bortoluzzi C.; Bortoluzzi M.; Brandolin B.; Casana R.; Ciammaichella M. M.; Giorgi-Pierfranceschi M.; Imbalzano E.; Lambertenghi-Deliliers D.; Pesavento R.; Pizzuti V.; Poz A.; Scandiuzzi-Piovesan T.; Scarinzi P.; Siniscalchi C.; Zalunardo B.; Cesnieks H.; Kigitovica D.; Skride A.; Tazi-Mezalek Z.; Fonseca S.; Marques R.; Meireles J.; Soeiro B.; Barco S.; Elbaranes N.; Rimann L.; Angiolillo D. J.; Caprini J. A.; Khalil A.; Ortega-Paz L.; Tafur A. J.; Weinberg I. |
| Contributors: | Hoberstorfer, T.; Nopp, S.; Steiner, D.; Hernandez-Blasco, L.; Jou, I.; Lopez-Nunez, J. J.; Fidalgo, A.; Lopez-Miguel, P.; Monreal, M.; Ay, C.; Prandoni, P.; Brenner, B.; Farge-Bancel, D.; Barba, R.; Verhamme, P.; Yoo, H. H. B.; Maly, R.; Bertoletti, L.; Schellong, S.; Tzoran, I.; Di Micco, P.; Reis, A.; Bosevski, M.; Mazzolai, L.; Joseph, A.; Caprini; Bui, H. M.; Adarraga, M. D.; Aibar, J.; Alberich-Conesa, A.; Alda-Lozano, A.; Alfonso, J.; Amado, C.; Angelina-Garcia, M.; Arcelus, J. I.; Ballaz, A.; Barbagelata, C.; Barron, M.; Barron-Andres, B.; Bencosme-de Mendez, E. I.; Blanco-Molina, A.; Bonavila, C. S.; Caballero, J. C.; Cantarella, R. F.; Chasco, L.; Claver, G.; Crecente, P.; Criado, J.; De Ancos-Aracil, C.; De Juana-Izquierdo, C.; Del Toro, J.; Demelo-Rodriguez, P.; Diaz-Brasero, A. M.; Diaz-Pedroche, M. C.; Diaz-Peromingo, J. A.; Dubois-Silva, A.; Duran, D.; Escribano, J. C.; Farfan-Sedano, A. I.; Fernandez-Bermejo, L. A.; Fernandez-Capitan, C.; Fernandez-Reyes, J. L.; Fidalgo, M. A.; Francisco, I.; Gabara, C.; Galeano-Valle, F.; Garcia-Bragado, F.; Garcia-Ortega, A.; Gavin-Sebastian, O.; Gil-Diaz, A.; Gomez-Cepeda, C.; Gomez-Cuervo, C.; Gonzalez-Martinez, J. G.; Gonzalez-Munera, A.; Gonzalez-Olmedo, J.; Gorostidi-Perez, J.; Grau, E.; Guirado, L.; Gutierrez-Guisado, J.; Heredia-Mena, C.; Hernandez-Vidal, M. J.; Jara-Palomares, L.; Jimenez, D.; Joya, M. D.; Lainez-Justo, S.; Lecumberri, R.; Llamas, P.; Lopez-Brull, H.; Lopez-Jimenez, L.; Lopez-Ruiz, A.; Lopez-Saez, J. B.; Lorenzo, A.; Madronal-Cerezo, E.; Maestre, A. |
| Publisher Information: | Elsevier B.V. |
| Publication Year: | 2025 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: | anticoagulant; hemorrhage; pulmonary embolism; recurrence; venous thrombosis |
| Description: | Background The VTE-PREDICT score predicts venous thromboembolism (VTE) recurrence and clinically relevant bleeding (CRB; major and clinically relevant nonmajor bleeding) after acute VTE. Objectives We aimed to externally validate the VTE-PREDICT score in the Registro Informatizado Enfermedad TromboEmbὀlica, a prospective registry of patients with VTE. Methods Exclusion criteria included enrollment before 2012, active cancer, and anticoagulation other than direct oral anticoagulants, vitamin K antagonists, or low-molecular-weight heparin. VTE recurrence and CRB risks were calculated using VTE-PREDICT for a prediction period of 3 months after the index VTE until the following 1 to 5 years. Predicted risks were then compared with observed risks. C-statistics and calibration plots were assessed. Results In total, 17 850 patients (50.3% women) were included in the final analysis, of whom 64.3% had pulmonary embolism. The median age was 67 years (IQR, 52-78). Regarding long-term anticoagulation, 21.8% of patients were treated with a direct oral anticoagulant, 39.9% with a vitamin K antagonist, and 4.8% with low-molecular-weight heparin, whereas 33.6% received no anticoagulant treatment. Cumulative incidences of VTE recurrence and CRB at 1 year were 3.7% (95% CI, 3.4%-4.0%) and 2.6% (95% CI, 2.4%-2.9%), respectively. The c-statistics of VTE-PREDICT for 1 to 5 years varied between 0.70 (95% CI, 0.67-0.72) and 0.73 (95% CI, 0.69-0.76) for VTE recurrence and between 0.65 (95% CI, 0.63-0.67) and 0.67 (95% CI, 0.64-0.70) for CRB. Calibration analysis revealed underestimation of VTE recurrence and overestimation of CRB risk. Conclusion VTE-PREDICT showed good discrimination for VTE recurrence and moderate discrimination for CRB, but underestimated the risk of VTE recurrence in high-risk patients. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40850342; info:eu-repo/semantics/altIdentifier/wos/WOS:001625754600012; volume:23; issue:12; firstpage:3909; lastpage:3919; numberofpages:11; journal:JOURNAL OF THROMBOSIS AND HAEMOSTASIS; https://hdl.handle.net/11577/3577482 |
| DOI: | 10.1016/j.jtha.2025.08.007 |
| Availability: | https://hdl.handle.net/11577/3577482; https://doi.org/10.1016/j.jtha.2025.08.007 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.5DF78F5D |
| Database: | BASE |