| Title: |
Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis |
| Authors: |
Yang JJ; Shu XO; Herrington DM; Moore SC; Meyer KA; Ose J; Menni C; Palmer ND; Eliassen H; Harada S; Tzoulaki I; Zhu HL; Albanes D; Wang TJ; Zheng W; Cai H; Ulrich CM; Guasch-Ferre M; Karaman I; Fornage M; Cai QY; Matthews CE; Wagenknecht LE; Elliott P; Gerszten RE; Yu DX |
| Contributors: |
J. Yang; X. Shu; D. Herrington; S. Moore; K. Meyer; J. Ose; C. Menni; N. Palmer; H. Eliassen; S. Harada; I. Tzoulaki; H. Zhu; D. Albane; T. Wang; W. Zheng; H. Cai; C. Ulrich; M. Guasch-Ferre; I. Karaman; M. Fornage; Q. Cai; C. Matthew; L. Wagenknecht; P. Elliott; R. Gerszten; D. Yu |
| Publication Year: |
2021 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
biomarker; cardiovascular disease; Consortium of Metabolomics Studie; diet; trimethylamine N-oxide; Settore MED/01 - Statistica Medica |
| Description: |
Background: Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host cometabolite, has been linked to cardiometabolic diseases. IIowever, the relations remain unclear between diet, TMAO, and cardiometabolic health in general populations from different regions and ethnicities. Objectives: To examine associations of circulating TMAO with dietary and cardiometabolic factors in a pooled analysis of 16 population-based studies from the United States, Europe, and Asia. Methods: Included were 32,166 adults (16,269 white, 13,293 Asian, 1247 I lispanic/Latino, 1236 black, and 121 others) without cardiovascular disease, cancer, chronic kidney disease, or inflammatory bowel disease. Linear regression coefficients (beta) were computed for standardized TMAO with harmonized variables. Study-specific results were combined by random-effects meta-analysis. A false discovery rate |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33826706; info:eu-repo/semantics/altIdentifier/wos/WOS:000652381000013; volume:113; issue:5; firstpage:1145; lastpage:1156; numberofpages:12; journal:THE AMERICAN JOURNAL OF CLINICAL NUTRITION; https://hdl.handle.net/2434/1095748 |
| DOI: |
10.1093/ajcn/nqaa430 |
| Availability: |
https://hdl.handle.net/2434/1095748; https://doi.org/10.1093/ajcn/nqaa430 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.5E3C92D7 |
| Database: |
BASE |