| Title: |
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal |
| Authors: |
Parra, EJ; Mazurek, A; Gignoux, CR; Sockell, A; Agostino, M; Morris, AP; Petty, LE; Hanis, CL; Cox, NJ; Valladares-Salgado, A; Below, JE; Cruz, M |
| Contributors: |
Mersha, Tesfaye B |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2017 |
| Collection: |
The University of Liverpool Repository |
| Description: |
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30±40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/ or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
Collapse authors list. Parra, EJ, Mazurek, A, Gignoux, CR, Sockell, A, Agostino, M, Morris, AP, Petty, LE, Hanis, CL, Cox, NJ, Valladares-Salgado, A et al (show 2 more authors) , Below, JE and Cruz, M (2017) Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal Plos One, 12 (2). e0172880-. ISSN 1932-6203, 1932-6203 |
| DOI: |
10.1371/journal.pone.0172880 |
| Availability: |
https://livrepository.liverpool.ac.uk/3006901/; https://doi.org/10.1371/journal.pone.0172880 |
| Accession Number: |
edsbas.5E4BE |
| Database: |
BASE |