| Title: |
How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium |
| Authors: |
Neesgaard, B; Mocroft, A; Greenberg, L; Larsen, JF; Wandeler, G; Zangerle, R; Gunthard, H; Smith, C; De Wit, S; Mussini, C; Castagna, A; Monforte, AD; Vehreschild, JJ; Wasmuth, J-C; Pradier, C; Chkhartishvili, N; Wit, FWNM; Law, M; Sonnerborg, A; Bruguera, A; Stephan, C; Vannappagari, V; Haubrich, R; Kirk, O; Podlekareva, D; Kowalska, J; Raben, D; Rockstroh, J; Peters, L; Parades, R; Grabmeier-Pfistershammer, K; Scherrer, A; Johnson, M; Necsoi, C; Borghi, V; Muccini, C; Tserstvadze, T; Petoumenos, K; Volny-Anne, A; Lundgren, J; Ryom, L |
| Source: |
Microorganisms , 8 (8) , Article 1164. (2020) |
| Publisher Information: |
MDPI |
| Publication Year: |
2020 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
HIV; cohort; observational study; hepatitis; public health; tuberculosis; pharmacovigilance |
| Description: |
Background: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases. Methods: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12. Results: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40–56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8–17.6), with 89.5% having a VL |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10110516/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10110516/1/microorganisms-08-01164-v2.pdf; https://discovery.ucl.ac.uk/id/eprint/10110516/ |
| Rights: |
open |
| Accession Number: |
edsbas.5E521B21 |
| Database: |
BASE |