| Title: |
Addressing thrombosis concerns in immune thrombocytopenia: the role of fostamatinib in immune thrombocytopenia management |
| Authors: |
Provan, Drew; Thachil, Jecko; Álvarez Roman, María Teresa |
| Contributors: |
Departamento de Medicina; Facultad de Medicina |
| Publisher Information: |
Taylor & Francis |
| Publication Year: |
2024 |
| Collection: |
Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| Subject Terms: |
bleeding; fostamatinib; immune thrombocytopenia; platelets; thromboembolism; Medicina |
| Description: |
Immune thrombocytopenia (ITP), a disease that commonly presents with an increased risk of bleeding, can also paradoxically produce an increased risk of thromboembolic events. The risk of thromboembolism can be associated with patient-related factors (e.g. co-morbidities, age and history of thrombosis), disease-related factors (e.g. a greater proportion of younger, more reactive platelets, and the presence of microparticles and pro-inflammatory cytokines) and treatment-related factors (e.g. splenectomy, thrombopoietin receptor agonists, and IVIg). Aspects of the pathophysiology of ITP and the effects of treatment are discussed with emphasis on individualizing treatment based on the patient’s thromboembolic risk, treatment options and preferences. An increased understanding of the pathophysiology of ITP has led to the development of new agents such as fostamatinib, a spleen tyrosine kinase inhibitor. Further research into the factors contributing to the risks for bleeding and thromboembolic events can contribute to the development of more specific therapies for ITP and allow greater individualization of therapy based on each patient’s medical history and clinical status ; The preparation and submission of this manuscript were funded by Grifols |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Expert Review of Hematology; https://doi.org/10.1080/17474086.2024.2318345; https://hdl.handle.net/10486/712690; 55; 66; 17 |
| DOI: |
10.1080/17474086.2024.2318345 |
| Availability: |
https://hdl.handle.net/10486/712690; https://doi.org/10.1080/17474086.2024.2318345 |
| Rights: |
© 2024 The Author(s) ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Reconocimiento – NoComercial – SinObraDerivada ; open access |
| Accession Number: |
edsbas.5E5AC989 |
| Database: |
BASE |