| Title: |
Prx1 + and Hic1+ Mesenchymal Progenitors Are Present Within the Epidural Fat and Dura Mater and Participate in Dural Injury Repair |
| Authors: |
Shah, Sophia; Mudigonda, Sathvika; Underhill, Tully Michael; Salo, Paul T; Mitha, Alim P; Krawetz, Roman J |
| Contributors: |
Natural Sciences and Engineering Research Council of Canada |
| Source: |
Stem Cells Translational Medicine ; volume 11, issue 2, page 200-212 ; ISSN 2157-6564 2157-6580 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Epidural fat is commonly discarded during spine surgery to increase the operational field. However, mesenchymal progenitor cells (MPCs) have now been identified in human epidural fat and within the murine dura mater. This led us to believe that epidural fat may regulate homeostasis and regeneration in the vertebral microenvironment. Using two MPC lineage tracing reporter mice (Prx1 and Hic1), not only have we found that epidural fat MPCs become incorporated in the dura mater over the course of normal skeletal maturation, but have also identified these cells as an endogenous source of repair and regeneration post-dural injury. Moreover, our results reveal a partial overlap between Prx1+ and Hic1+ populations, indicating a potential hierarchical relationship between the two MPC populations. This study effectively challenges the notion of epidural fat as an expendable tissue and mandates further research into its biological function and relevance. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/stcltm/szab014 |
| Availability: |
https://doi.org/10.1093/stcltm/szab014; https://academic.oup.com/stcltm/article-pdf/11/2/200/42947213/szab014.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.5E5EE4A3 |
| Database: |
BASE |