Evolution of transmitted HIV-1 drug resistance and viral subtypes circulation in Italy from 2006 to 2016
| Title: | Evolution of transmitted HIV-1 drug resistance and viral subtypes circulation in Italy from 2006 to 2016 |
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| Authors: | Rossetti B.; Di Giambenedetto S.; Torti C.; Postorino M. C.; Punzi G.; Saladini F.; Gennari W.; Borghi V.; Monno L.; Pignataro A. R.; Polilli E.; Colafigli M.; Poggi A.; Tini S.; Zazzi M.; De Luca A.; Mellace V.; Capetti A.; Gismondo M. R.; Biondi M. L.; Mussini C.; Pecorari M.; Gianotti N.; Sacchini D.; Parruti G.; Baldelli F.; Zanussi S.; Nerli A.; Lenzi L.; Calzetti C.; Vivarelli A.; Maserati R.; Baldanti F.; Poletti F.; Mondino V.; Malena M.; Cascio A.; Filice G.; Magnani G.; Zerbini A.; Lombardi F.; Di Gaimbenedetto S.; Andreoni M.; Montano M.; Vullo V.; Turriziani O.; Gonnelli A.; Boeri E.; Bonora S.; Ghisetti V.; Francisci D.; Grossi P.; Bagnarelli P.; Butini L.; del Gobbo R.; Giacometti A.; Tacconi D.; Callegaro A.; Maggiolo F.; Zoncada A.; Paolini E.; Sighinolfi L.; Colao G.; Corsi P.; Blanc P.; Galli L.; Meraviglia P.; Tosti A.; Bruzzone B.; Setti M.; Penco G.; Di Biagio A.; Nencioni C.; Pardelli R.; Arcidiacono I.; Degiuli A.; De Gennaro M.; Soria A.; Foc A.; Latella S.; Cosco L.; Malandrin S.; Milini P.; Cicconi P.; Rusconi S.; Micheli V. |
| Contributors: | B. Rossetti; S. Di Giambenedetto; C. Torti; M.C. Postorino; G. Punzi; F. Saladini; W. Gennari; V. Borghi; L. Monno; A.R. Pignataro; E. Polilli; M. Colafigli; A. Poggi; S. Tini; M. Zazzi; A. De Luca; V. Mellace; A. Capetti; M.R. Gismondo; M.L. Biondi; C. Mussini; M. Pecorari; N. Gianotti; D. Sacchini; G. Parruti; F. Baldelli; S. Zanussi; A. Nerli; L. Lenzi; C. Calzetti; A. Vivarelli; R. Maserati; F. Baldanti; F. Poletti; V. Mondino; M. Malena; A. Cascio; G. Filice; G. Magnani; A. Zerbini; F. Lombardi; S. Di Gaimbenedetto; M. Andreoni; M. Montano; V. Vullo; O. Turriziani; A. Gonnelli; E. Boeri; S. Bonora; V. Ghisetti; D. Francisci; P. Grossi; P. Bagnarelli; L. Butini; R. del Gobbo; A. Giacometti; D. Tacconi; A. Callegaro; F. Maggiolo; A. Zoncada; E. Paolini; L. Sighinolfi; G. Colao; P. Corsi; P. Blanc; L. Galli; P. Meraviglia; A. Tosti; B. Bruzzone; M. Setti; G. Penco; A. Di Biagio; C. Nencioni; R. Pardelli; I. Arcidiacono; A. Degiuli; M. De Gennaro; A. Soria; A. Foc; S. Latella; L. Cosco; S. Malandrin; P. Milini; P. Cicconi; S. Rusconi; V. Micheli |
| Publisher Information: | Wiley |
| Publication Year: | 2018 |
| Collection: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: | antiretroviral therapy; HIV; recent HIV infection; resistance epidemiology; transmitted HIV drug resistance; Adult; Anti-HIV Agent; CD4 Lymphocyte Count; Female; HIV Infection; HIV-1; Human; Italy; Male; Middle Aged; Mutation; Odds Ratio; Prevalence; Viral Protein; Drug Resistance; Viral; Settore MED/17 - Malattie Infettive |
| Description: | Objectives: The aim was to evaluate the evolution of transmitted HIV-1 drug resistance (TDR) prevalence in antiretroviral therapy (ART)-naïve patients from 2006 to 2016. Methods: HIV-1 sequences were retrieved from the Antiviral Response Cohort Analysis (ARCA) database and TDR was defined as detection of at least one mutation from the World Health Organization (WHO) surveillance list. Results: We included protease/reverse transcriptase sequences from 3573 patients; 455 had also integrase sequences. Overall, 68.1% of the patients were Italian, the median CD4 count was 348 cells/μL [interquartile range (IQR) 169–521 cells/μL], and the median viral load was 4.7 log 10 HIV-1 RNA copies/mL (IQR 4.1–5.3 log 10 copies/mL). TDR was detected in 10.3% of patients: 6% carried mutations to nucleos(t)ide reverse transcriptase inhibitors (NRTIs), 4.4% to nonnucleos(t)ide reverse transcriptase inhibitors (NNRTIs), 2.3% to protease inhibitors (PIs), 0.2% to integrase strand transfer inhibitors (INSTIs) and 2.1% to at least two drug classes. TDR declined from 14.5% in 2006 to 7.3% in 2016 (P=0.003): TDR to NRTIs from 9.9 to 2.9% (P=0.003) and TDR to NNRTIs from 5.1 to 3.7% (P=0.028); PI TDR remained stable. The proportion carrying subtype B virus declined from 76.5 to 50% (P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29932313; info:eu-repo/semantics/altIdentifier/wos/WOS:000443397400005; volume:19; issue:9; firstpage:619; lastpage:628; numberofpages:10; journal:HIV MEDICINE; https://hdl.handle.net/2434/699202 |
| DOI: | 10.1111/hiv.12640 |
| Availability: | https://hdl.handle.net/2434/699202; https://doi.org/10.1111/hiv.12640 |
| Rights: | info:eu-repo/semantics/closedAccess |
| Accession Number: | edsbas.5E79DED8 |
| Database: | BASE |