| Title: |
Quality improvement interventions to increase the uptake of magnesium sulphate in preterm deliveries for the prevention of cerebral palsy (PReCePT study):a cluster randomised controlled trial |
| Authors: |
Edwards , Hannah B; Redaniel, Maria Theresa; Sillero Rejon, Carlos; Pithara-McKeown, Christalla; Margelyte, Ruta; Stone, Tracey J; Peters, TJ; Hollingworth, William; McLeod, Hugh S T; Craggs, Pippa; Hill, Elizabeth M; Redwood, Sabi M; Treloar, Emma J; Donovan , Jenny L; Opmeer, Brent C; Luyt, Karen |
| Source: |
Edwards , H B, Redaniel, M T, Sillero Rejon, C, Pithara-McKeown, C, Margelyte, R, Stone, T J, Peters, TJ, Hollingworth, W, McLeod, H S T, Craggs, P, Hill, E M, Redwood, S M, Treloar, E J, Donovan , J L, Opmeer, B C & Luyt, K 2024, 'Quality improvement interventions to increase the uptake of magnesium sulphate in preterm deliveries for the prevention of cerebral palsy (PReCePT study) : a cluster randomised controlled trial', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 131, no. 3, pp. 256-266. https://doi.org/10.1111/1471-0528.17651 |
| Publication Year: |
2024 |
| Collection: |
University of Bristol: Bristol Reserach |
| Subject Terms: |
/dk/atira/pure/core/keywords/fohsheb; name=HEHP@Bristol; /dk/atira/pure/core/keywords/nihr_arc_west; name=NIHR ARC West; Obstetrics; Midwifery; Pregnancy; Infant; Premature; Extremely Premature; Cerebral Palsy; Magnesium Sulfate; Quality Improvement; Randomized Controlled Trials |
| Description: |
Objective: Compare two Quality Improvement (QI) interventions to improve antenatal magnesium sulfate (MgSO4) uptake in preterm births for prevention of Cerebral Palsy. Design: Unblinded cluster randomised controlled trial. Setting: England, Academic Health Sciences Network, 2018. Participants: Maternity units with ≥10 preterm deliveries annually and MgSO4 uptake ≤70%. 40 (27 NPP, 13 enhanced support) were included (randomisation stratified by MgSO4 uptake). Interventions: The National PReCePT Programme (NPP) gave maternity units QI materials (clinical guidance, training), regional support, and midwife backfill funding. Enhanced support units received this plus extra backfill funding and unit-level QI coaching. Outcome measures: MgSO4 uptake was compared using routine data and multivariable linear regression. Net monetary benefit was estimated, based on implementation costs, lifetime quality-adjusted life-years and societal costs. Implementation process was assessed through qualitative interviews. Results: MgSO4 uptake increased in all units, with no evidence of difference between groups (0.84 percentage points lower uptake in the enhanced group, 95% CI -5.03 to 3.35). The probability of enhanced support being cost-effective was |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37691262; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/442febe2-267a-4509-9440-94b420bb3aae |
| DOI: |
10.1111/1471-0528.17651 |
| Availability: |
https://hdl.handle.net/1983/442febe2-267a-4509-9440-94b420bb3aae; https://research-information.bris.ac.uk/en/publications/442febe2-267a-4509-9440-94b420bb3aae; https://doi.org/10.1111/1471-0528.17651; https://research-information.bris.ac.uk/ws/files/379147570/PReCePT_trial_paper_BJOG_2023.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5EA08126 |
| Database: |
BASE |