| Title: |
ChemBioFrance small molecules for health and research ; ChemBioFrance de petites molécules pour comprendre et soigner le vivant |
| Authors: |
Bonnet, Pascal; Mahuteau-Betzer, Florence; Le Clech, Mikaël; Tran, Kiet |
| Contributors: |
Institut de Chimie Organique et Analytique (ICOA); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Université d'Orléans (UO); Institut Curie Paris; Institut de Génétique Moléculaire de Montpellier (IGMM); Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) |
| Source: |
RICT 2025 - 59th International Conference on Medicinal Chemistry ; https://hal.science/hal-05151514 ; RICT 2025 - 59th International Conference on Medicinal Chemistry, Jul 2025, Orléans, France |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Collection: |
Université d'Orléans: HAL |
| Subject Terms: |
Chemical Library; Screening; Chemoinformatics; ADME; ChemBioFrance; [CHIM]Chemical Sciences; [SDV]Life Sciences [q-bio] |
| Subject Geographic: |
Orléans; France |
| Description: |
International audience ; ChemBioFrance research infrastructure, launched in October 2018, brings together researchers and engineers from the academic world, experts in the design and discovery of biologically active molecules and in optimizing their properties. It welcomes users seeking to treat common or rare, orphan or emerging diseases, to target resistance phenomena, and more generally to understand the living world.ChemBioFrance relies on approximately seventy researchers and engineers, who combine their expertise in chemistry, biochemistry, physiology, and model biological systems to accelerate the discovery and development of drug candidates. An offering based on complementary expertise ChemBioFrance is organized around four pillars, coordinated by a support unit based in Montpellier, which also manages user relationships and handles all operational aspects of the infrastructure. The four pillars are: •The National Chemical Library, a unique collection of 99,000 molecules and 15,500 natural extracts, centralized in Montpellier and compiled by a national network of 45 public laboratories. Users can access the molecules they wish to test on biological models, as well as the information associated with each molecule.•A network of eight chemoinformatics laboratories models the structure of biological targets, the physicochemical properties of the molecules in the chemical library, and the interactions between target and molecule. The network analyzes experimental measurements and guides the optimization of biological activity.•A network of nine screening platforms experimentally tests the activity of molecules on biological systems ranging from simple (an isolated biological target) to highly complex (an entire organism) in controlled environments. It selects the most active molecules best suited for their future use.•A network of ADME toxicology platforms conducts absorption, distribution, metabolism/elimination, and toxicology studies of new molecules on molecular, cellular, and animal models. This service ... |
| Document Type: |
conference object; still image |
| Language: |
English |
| Availability: |
https://hal.science/hal-05151514; https://hal.science/hal-05151514v1/document; https://hal.science/hal-05151514v1/file/Poster_chembiofrance_vf.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5F2FBD28 |
| Database: |
BASE |