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Genetic alterations of ALK in high-risk neuroblastoma patients: a SIOPEN study

Title: Genetic alterations of ALK in high-risk neuroblastoma patients: a SIOPEN study
Authors: Bellini, Angela; Bernard, Virginie; Ambros, Inge; Ambros, Peter F.; de Preter, Katleen; Combaret, Valérie; Beiske, Klaus; Jeison, Marta; Marques, Barbara; Morini, Martina; Mazzocco, Katia; Defferrari, Raffaella; Betts, David; Martinsson, Tommy; Mühlethaler-Mottet, Annick; Noguera, Rosa; Font de Mora, Jaime; Vicha, Ales; Ladenstein, Ruth; Valteau-Couanet, Dominique; Rossing, Caroline Maria; Bown, Nick; Tweddle, Deborah; Avigad, Smadar; Lapouble, Eve; Chicard, Mathieu; Leprovost, Nada; Clement, Nathalie; Baulande, Sylvain; Pierron, Gaelle; Irene, Jimenez; Jaydutt, Bhalshankar; Delattre, Olivier; Michon, Jean; Schleiermacher, Gudrun
Publication Year: 2019
Collection: National Health Institute, Portugal: Repositório Científico
Subject Terms: Neuroblastoma; ALK; Tumor Genomics; Doenças Genéticas
Description: Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated either through genomic amplification or activating point mutations. We studied ALK genetic alterations in high-risk NB patients to determine their frequency and prognostic impact. ; N/A
Document Type: conference object
Language: English
Relation: http://hdl.handle.net/10400.18/5900
Availability: http://hdl.handle.net/10400.18/5900
Rights: openAccess ; http://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.5F543403
Database: BASE