| Title: |
Abstract P2075: Impact of a Minimally Processed Provegetarian Diet on LDL-cholesterol and Cardiovascular Risk Factors in Adults with Heterozygous Familial Hypercholesterolemia: a Randomized Controlled Feeding Trial |
| Authors: |
Lessard-Lord, Jacob; Guay, Valerie; Rancourt-Bouchard, Maryka; Couture, Patrick; Gangloff, Anne; Blais, Jonatan; Drouin-Chartier, Jean-Philippe |
| Source: |
Circulation ; volume 151, issue Suppl_1 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
Introduction: Heterozygous familial hypercholesterolemia (HeFH) is a severe genetic disorder that accelerates atherosclerosis and leads to premature cardiovascular diseases (CVDs). Minimally processed provegetarian diets are recommended in dietary and clinical guidelines worldwide for their cardioprotective properties. However, the impact of such diet on LDL-cholesterol (LDL-C) and other CVD risk factors has not yet been assessed in fully controlled feeding settings among adults with HeFH. Hypothesis: We tested the hypothesis that a minimally processed provegetarian diet (MPVD) induces clinically significant improvements in plasma LDL-C levels (primary outcome) and other CVD risk factors compared to a standard American diet (SAD) among adults with HeFH. Methods: In this randomized, crossover, controlled feeding trial, 50 adults with genetically confirmed HeFH, free of cholesterol-lowering medication, consumed a MPVD and a SAD for 4 weeks each in a random order under fully controlled feeding conditions. Fasting plasma atherogenic lipid levels and other CVD risk factors were measured at the end of each diet. Results: Relative to the SAD, the MPVD induced a clinically significant reduction in LDL-C (−18.6%, 95% confidence interval (CI) −22.1%, −15.2%; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/cir.151.suppl_1.p2075 |
| Availability: |
https://doi.org/10.1161/cir.151.suppl_1.p2075 |
| Accession Number: |
edsbas.5F793680 |
| Database: |
BASE |