| Title: |
Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer’s disease: neuropsychiatric symptoms, co-pathologies, and sex differences |
| Authors: |
Shwab, EK; Pathak, G; Harvey, J; Belloy, ME; Fischer, CE; Lutz, MW; Scholz, SW; Cook, N; Reid, DM; Chen, J; Guan, DX; Oliveira, F; Sinclair, LI; Imo, U; Creese, B; Chiba-Falek, O |
| Publisher Information: |
Wiley on behalf of the Alzheimer's Association |
| Publication Year: |
2025 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
Alzheimer's disease; co-pathologies; disease heterogeneity; disease subtypes; epigenomics; genetic diversity; multiomics; neuropsychiatric symptoms; proteomics; quantitative trait locus mapping; sex differences; single-cell sequencing; spatial omics; transcriptomics; translational science |
| Description: |
At end of the list of authors: Neuropsychiatric Syndromes Professional Interest Area MultiomicsWork Group, Alzheimer’s Association, International Society to Advance Alzheimer’s Research and Treatment, Chicago, Illinois, USA ; Supporting Information is available online at: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70549#support-information-section . ; The heterogeneity of Alzheimer's disease (AD) is multi-dimensional, encompassing clinical features such as neuropsychiatric symptoms (NPS), rate of progression, age of onset, comorbidities, and neuropathological features such as co-pathologies, and represents the diverse outcomes of manifold genetic and environmental risk determinants. These diverse features of AD also vary significantly between sexes and across ancestral backgrounds, but the specific variations and causal mechanisms are not well understood. Recent technological advances, particularly single-cell and spatial omics, have provided new tools to dissect the molecular underpinnings of AD heterogeneity and its multifactorial nature. This perspective review highlights molecular differences, general and sex-specific, that contribute to the heterogeneity of AD in aspects such as NPS, co-pathology prevalence, and general disease trajectories. We further examined the potential for multiomic approaches to direct future translational studies aimed at the development of precision medicine strategies for the treatment of AD in all its diverse forms. ; National Institutes of Health/National Institute on Aging. Grant Numbers: R01 AG057522, RF1 AG077695, R00AG078503, R00AG075238, R01AG067015; National Institute of Neurological Disorders & Stroke. Grant Numbers: RF1-NS113548-01A1, ZIANS003154; National Institute on Alcohol Abuse and Alcoholism. Grant Number: 2U10AA008401; Cure Alzheimer's Fund; The State of São Paulo Research Foundation. Grant Number: 2015/10109-5; Alzheimer's Association. Grant Numbers: AARG-24-1027303, 22-AAIIA-953269, AARF-22-967171. |
| Document Type: |
article in journal/newspaper |
| File Description: |
1 - 24; Print-Electronic |
| Language: |
English |
| Relation: |
Alzheimer's and Dementia; https://bura.brunel.ac.uk/handle/2438/31761 |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/31761 |
| Rights: |
Creative Commons Attribution-NonCommercial 4.0 International ; https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/legalcode.en ; The Author(s) |
| Accession Number: |
edsbas.5F93905B |
| Database: |
BASE |