| Title: |
Eligibility for Icosapent ethyl in patients undergoing cardiac rehabilitation: A real-world cohort study |
| Authors: |
Brucato F.; Tognola C.; Moreo A.; Bellomare M.; Prencipe G. P.; Lettino M.; Trocino G.; Dadone V.; Pierini S.; Viola G.; Oliva F.; Merlini P.; Giannattasio C.; Maloberti A. |
| Contributors: |
Brucato, F; Tognola, C; Moreo, A; Bellomare, M; Prencipe, G; Lettino, M; Trocino, G; Dadone, V; Pierini, S; Viola, G; Oliva, F; Merlini, P; Giannattasio, C; Maloberti, A |
| Publisher Information: |
Elsevier/North-Holland; NL |
| Publication Year: |
2026 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Cardiac rehabilitation; Cardiovascular prevention; Eicosapentaenoic acid; Hypertriglyceridemia; Icosapent ethyl; Lipid management; Residual cardiovascular risk |
| Description: |
Introduction: Despite optimal lipid-lowering therapy, many patients with established cardiovascular disease (CVD) maintain elevated triglyceride (TG) levels, contributing to residual risk. Icosapent ethyl (IPE) has shown clinical benefit in patients with moderate hypertriglyceridemia. This study aimed to evaluate eligibility for IPE treatment based on REDUCE-IT and Italian Drugs Administration (AIFA) eligibility criteria. Methods: We retrospectively analyzed 1129 patients referred to a cardiac rehabilitation program for a recent acute coronary syndromes or with a chronic coronary syndromes between 2012 and 2025. Fasting TG and LDL were assessed at admission and discharge. We identified patients eligible for IPE treatment based on REDUCE-IT (TG 135–499 mg/dL, LDL 40–100 mg/dL, statin therapy) and AIFA eligibility criteria (TG ≥200 mg/dL, LDL |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41309000; info:eu-repo/semantics/altIdentifier/wos/WOS:001631483100001; volume:445; issue:February 15, 2026; firstpage:1; lastpage:6; numberofpages:6; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY; https://hdl.handle.net/10281/582122 |
| DOI: |
10.1016/j.ijcard.2025.134046 |
| Availability: |
https://hdl.handle.net/10281/582122; https://doi.org/10.1016/j.ijcard.2025.134046 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5F94E99F |
| Database: |
BASE |