| Title: |
Cerebrovascular Reactivity Assessment with Breath-Hold Functional MRI in Patients with Moyamoya Angiopathy: Which Time Period to Analyze? |
| Authors: |
Leonie Zerweck; Uwe Klose; Constantin Roder; Nadia Khan; Philipp T. Meyer; Ulrike Ernemann; Till-Karsten Hauser |
| Source: |
Diagnostics ; Volume 16 ; Issue 6 ; Pages: 904 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2026 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
Moyamoya Angiopathy; cerebrovascular reactivity; breath-hold functional MRI; [ 15 O]water PET |
| Description: |
Background/Objectives: Quantifying cerebrovascular reactivity (CVR) is essential for stroke risk assessment in patients with Moyamoya Angiopathy (MMA). Breath-hold functional MRI (bh-fMRI) is an easily implementable method to assess CVR. Determining the optimal time period of the BOLD signal for analyzing the best bh-fMRI data quality remains an open question. Methods: A retrospective analysis of 46 bh-fMRI data sets of MMA patients was conducted. The percentage BOLD signal changes were evaluated at different time periods (time point of the maximum cerebellar signal peak (TPcereb. max) ± 0 s, TPcereb. max ± 1 s, TPcereb. max ± 2 s, TPcereb. max ± 3 s, TPcereb. max ± 4 s, TPcereb. max ± 5 s). The agreement between the bh-fMRI maps and [15O]water PET maps was independently and consensually rated on a 4-point Likert scale (1 = poor, 2 = moderate, 3 = good, 4 = excellent) and compared with the Friedman test. The inter-rater agreement was calculated separately for each time period using quadratic weighted Cohen’s kappa κw. Results: The selected time period had a significant impact on the agreement between bh-fMRI and [15O]water PET (χ2(5) = 79.448, p < 0.001, W = 0.345). Short time periods of TPcereb.max ± 0 s or TPcereb.max ±1 s demonstrated the highest level of concordance between bh-fMRI and [15O]water PET (median = 3.5 for TPcereb.max ± 0 s; median = 3 for TPcereb.max ± 1 s, modus = 4 in both cases). The agreement between bh-fMRI and [15O]water PET was significantly higher when evaluating time periods of TPcereb.max ± 0 s than when evaluating all time periods ≥ TPcereb. max ± 2 s. The inter-rater agreement was almost perfect for all time periods except one (TPcereb. max ± 1 s). Conclusions: Short time periods should be selected when evaluating CVR with bh-fMRI, as this study suggests a high level of validity in comparison to [15O]water PET. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Clinical Diagnosis and Prognosis; https://dx.doi.org/10.3390/diagnostics16060904 |
| DOI: |
10.3390/diagnostics16060904 |
| Availability: |
https://doi.org/10.3390/diagnostics16060904 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5FCBF7A9 |
| Database: |
BASE |